https://scholars.lib.ntu.edu.tw/handle/123456789/474958
標題: | Infective endocarditis caused by nutritionally variant streptococci | 作者: | Lin C.-H. RON-BIN HSU |
關鍵字: | Infective endocarditis; Nutritionally variant streptococci | 公開日期: | 2007 | 出版社: | Lippincott Williams and Wilkins | 卷: | 334 | 期: | 4 | 起(迄)頁: | 235-239 | 來源出版物: | American Journal of the Medical Sciences | 摘要: | BACKGROUND: Infective endocarditis caused by nutritionally variant streptococci (NVS) has a higher rate of complications than endocarditis caused by other streptococci. The bacteriologic failure rate and the mortality rate are high. However, current knowledge on this disease derives from previous patient data from 1987. Recent case reports showed successful antibiotic treatment in the absence of surgery. Here, we report the clinical outcome of infective endocarditis caused by NVS in our hospital. METHODS: Data were collected by retrospective case note review. RESULTS: Between 1996 and 2006, there were 8 cases of NVS endocarditis: 4 patients had infection caused by Abiotrophia defectiva and 4 patients had infection caused by Granulicatella adiacens. Vegetation size on echocardiography was large (10 mm) in 7 patients, and embolization occurred in 3 patients. Patients were treated with penicillin and gentamicin initially, and 3 of them were successfully treated. The regimens were shifted to vancomycin, teicoplanin, or cefotaxime in 2 cases because of poor therapeutic responses. A total of 4 patients underwent early valve replacement successfully because of severe heart failure. Three patients underwent mitral valve repair successfully at the time of 2, 4, and 7 months after the diagnosis of endocarditis. The valve cultures at surgery were negative. There was no mortality or relapse. The bacteriologic failure rate was zero. CONCLUSIONS: Antibiotic treatment with penicillin and gentamicin had a high rate of success in patients with infective endocarditis caused by NVS. Early surgical intervention should be considered in those patients with deteriorating heart failure due to valve destruction. ? Copyright 2007 Southern Society for Clinical Investigation. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-38449122412&doi=10.1097%2fMAJ.0b013e3180a6eeab&partnerID=40&md5=512670c75124189d66cb5e2f2a8b6281 https://scholars.lib.ntu.edu.tw/handle/123456789/474958 |
ISSN: | 0002-9629 | DOI: | 10.1097/MAJ.0b013e3180a6eeab | SDG/關鍵字: | beta lactam; cefotaxime; ceftriaxone; gentamicin; penicillin G sodium; rifampicin; teicoplanin; vancomycin; antiinfective agent; gentamicin; penicillin derivative; Abiotrophia defectiva; adult; article; artificial embolism; bacterial endocarditis; endocarditis; female; Granulicatella adiacens; heart failure; heart valve replacement; human; information processing; major clinical study; male; mitral valve repair; mortality; relapse; retrospective study; school child; Streptococcus; treatment outcome; treatment response; vegetation; adolescent; aged; alpha hemolytic Streptococcus; child; cross infection; endocarditis; heart failure; microbiology; middle aged; mitral valve regurgitation; pathogenicity; penicillin resistance; Adolescent; Adult; Aged; Anti-Bacterial Agents; Child; Cross Infection; Endocarditis; Female; Gentamicins; Heart Failure; Humans; Male; Middle Aged; Mitral Valve Insufficiency; Penicillin Resistance; Penicillins; Retrospective Studies; Viridans Streptococci |
顯示於: | 醫學系 |
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