https://scholars.lib.ntu.edu.tw/handle/123456789/476125
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chen Y. | en_US |
dc.contributor.author | Lee C.-H. | en_US |
dc.contributor.author | Tseng B.-Y. | en_US |
dc.contributor.author | Tsai Y.-H. | en_US |
dc.contributor.author | Tsai H.-W. | en_US |
dc.contributor.author | Yao C.-L. | en_US |
dc.contributor.author | SHENG-HONG TSENG | en_US |
dc.creator | Chen Y.;Lee C.-H.;Tseng B.-Y.;Tsai Y.-H.;Tsai H.-W.;Yao C.-L.;Sheng-Hong Tseng | - |
dc.date.accessioned | 2020-03-12T08:24:31Z | - |
dc.date.available | 2020-03-12T08:24:31Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043420383&doi=10.21873%2fanticanres.12369&partnerID=40&md5=99b3f43255f9fbe9b90e02f833927f17 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/476125 | - |
dc.description.abstract | Background/Aim: AZD8055 is an inhibitor of mammalian target of rapamycin (mTOR) that can suppress both mTOR complex 1 (mTORC1) and mTORC2. This study investigated the antitumor effects of AZD8055 on colon cancer. Materials and Methods: The effects of AZD8055 on proliferation, apoptosis, and cell cycle of colon cancer cells, and tumor growth in a mouse colon cancer model were studied. Results: AZD8055 significantly inhibited proliferation and induced apoptosis of colon cancer cells (p<0.05). The phosphorylation of both AKT and S6 kinase 1 (S6K1) was suppressed by AZD8055. AZD8055 also induced G0/G1 cell-cycle arrest, reduced cyclin D1 and increased p27 expression, and suppressed the levels of phospho-cyclin-dependent kinase 2 and phospho-retinoblastoma. Compared to the control, oral administration of AZD8055 significantly suppressed tumor growth in mice (p<0.05). Conclusion: AZD8055 induces cytotoxicity, apoptosis, and cell-cycle arrest of colon cancer cells, and exerts an antitumor effect in mice. It also inhibits the mTOR signaling pathway and mTOR-dependent cell-cycle progression. ? 2018 International Institute of Anticancer Research. All rights reserved. | - |
dc.publisher | International Institute of Anticancer Research | - |
dc.relation.ispartof | Anticancer Research | - |
dc.subject | Apoptosis; AZD8055; Cell cycle; Colon cancer; MTOR | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | azd 8055; cyclin D1; cyclin dependent kinase 2; mammalian target of rapamycin; protein kinase B; protein p27; retinoblastoma protein; S6 kinase; S6 kinase 1; unclassified drug; (5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol; morpholine derivative; target of rapamycin kinase; animal experiment; animal model; antineoplastic activity; apoptosis; Article; cancer inhibition; cell cycle G0 phase; cell cycle progression; cell proliferation; cell viability; colon cancer; controlled study; down regulation; drug cytotoxicity; enzyme inhibition; enzyme phosphorylation; G1 phase cell cycle checkpoint; HCT 116 cell line; HCT 15 cell line; human; human cell; in vitro study; LC50; male; mouse; mTOR signaling; nonhuman; priority journal; protein expression; upregulation; animal; antagonists and inhibitors; Bagg albino mouse; cell survival; colon tumor; drug effects; experimental neoplasm; metabolism; pathology; signal transduction; tumor cell line; tumor volume; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; G1 Phase Cell Cycle Checkpoints; HCT116 Cells; Humans; Male; Mice, Inbred BALB C; Morpholines; Neoplasms, Experimental; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Burden | - |
dc.title | AZD8055 exerts antitumor effects on colon cancer cells by inhibiting mTOR and cell-cycle progression | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.21873/anticanres.12369 | - |
dc.identifier.pmid | 29491070 | - |
dc.identifier.scopus | 2-s2.0-85043420383 | - |
dc.relation.pages | 1445-1454 | - |
dc.relation.journalvolume | 38 | - |
dc.relation.journalissue | 3 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.orcid | 0000-0002-9959-9206 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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