https://scholars.lib.ntu.edu.tw/handle/123456789/476417
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lai C.-Y. | en_US |
dc.contributor.author | SUNG-LIANG YU | en_US |
dc.contributor.author | MING-HSIEN HSIEH | en_US |
dc.contributor.author | Chen C.-H. | en_US |
dc.contributor.author | Chen H.-Y. | en_US |
dc.contributor.author | Wen C.-C. | en_US |
dc.contributor.author | Huang Y.-H. | en_US |
dc.contributor.author | Hsiao P.-C. | en_US |
dc.contributor.author | CHUHSING KATE HSIAO | en_US |
dc.contributor.author | Liu C.-M. | en_US |
dc.contributor.author | PAN-CHYR YANG | en_US |
dc.contributor.author | Hwu H.-G. | en_US |
dc.contributor.author | WEI J. CHEN | en_US |
dc.creator | Lai C.-Y.;Yu S.-L.;Ming-Hsien Hsieh;Chen C.-H.;Chen H.-Y.;Wen C.-C.;Huang Y.-H.;Hsiao P.-C.;Hsiao C.K.;Liu C.-M.;Yang P.-C.;Hwu H.-G.;Chen W.J. | - |
dc.date.accessioned | 2020-03-17T06:22:51Z | - |
dc.date.available | 2020-03-17T06:22:51Z | - |
dc.date.issued | 2011 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/476417 | - |
dc.description.abstract | Since brain tissue is not readily accessible, a new focus in search of biomarkers for schizophrenia is blood-based expression profiling of non-protein coding genes such as microRNAs (miRNAs), which regulate gene expression by inhibiting the translation of messenger RNAs. This study aimed to identify potential miRNA signature for schizophrenia by comparing genome-wide miRNA expression profiles in patients with schizophrenia vs. healthy controls. A genome-wide miRNA expression profiling was performed using a Taqman array of 365 human miRNAs in the mononuclear leukocytes of a learning set of 30 cases and 30 controls. The discriminating performance of potential biomarkers was validated in an independent testing set of 60 cases and 30 controls. The expression levels of the miRNA signature were then evaluated for their correlation with the patients' clinical symptoms, neurocognitive performances, and neurophysiological functions. A seven-miRNA signature (hsa-miR-34a, miR-449a, miR-564, miR-432, miR-548d, miR-572 and miR-652) was derived from a supervised classification with internal cross-validation, with an area under the curve (AUC) of receiver operating characteristics of 93%. The putative signature was then validated in the testing set, with an AUC of 85%. Among these miRNAs, miR-34a was differentially expressed between cases and controls in both the learning (P = 0.005) and the testing set (P = 0.002). These miRNAs were differentially correlated with patients' negative symptoms, neurocognitive performance scores, and event-related potentials. The results indicated that the mononuclear leukocyte-based miRNA profiling is a feasible way to identify biomarkers for schizophrenia, and the seven-miRNA signature warrants further investigation. ? 2011 Lai et al. | en_US |
dc.relation.ispartof | PLoS ONE | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | biological marker; microRNA; microRNA 34a; microRNA 432; microRNA 449a; microRNA 548d; microRNA 564; microRNA 572; microRNA 652; RNA; unclassified drug; biological marker; microRNA; area under the curve; article; bioassay; clinical feature; controlled study; disease marker; gene expression profiling; genetic association; genetic disorder; genetic identification; genetic marker; genome analysis; human; major clinical study; mental performance; mononuclear cell; negative syndrome; neuropsychological test; schizophrenia; validation process; blood; case control study; Biological Markers; Case-Control Studies; Humans; MicroRNAs; Schizophrenia | - |
dc.title | MicroRNA expression Aberration as potential peripheral blood biomarkers for Schizophrenia | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1371/journal.pone.0021635 | - |
dc.identifier.pmid | 21738743 | - |
dc.identifier.scopus | 2-s2.0-79959663462 | - |
dc.relation.journalvolume | 6 | en_US |
dc.relation.journalissue | 6 | en_US |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Medical Device and Imaging | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Public Health | - |
crisitem.author.dept | Institute of Health Data Analytics and Statistics | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Oncology | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | Public Health | - |
crisitem.author.dept | Brain and Mind Sciences | - |
crisitem.author.orcid | 0000-0003-4535-9036 | - |
crisitem.author.orcid | 0000-0002-3585-7843 | - |
crisitem.author.orcid | 0000-0003-4905-8484 | - |
crisitem.author.orcid | 0000-0001-6330-6048 | - |
crisitem.author.orcid | 0000-0001-5899-5870 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Medicine | - |
Appears in Collections: | 醫學系 |
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