https://scholars.lib.ntu.edu.tw/handle/123456789/476445
DC 欄位 | 值 | 語言 |
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dc.contributor.author | Liu Y.-L. | en_US |
dc.contributor.author | Fann C.S.-J. | en_US |
dc.contributor.author | Liu C.-M. | en_US |
dc.contributor.author | WEI J. CHEN | en_US |
dc.contributor.author | Wu J.-Y. | en_US |
dc.contributor.author | Hung S.-I. | en_US |
dc.contributor.author | Chen C.-H. | en_US |
dc.contributor.author | Jou Y.-S. | en_US |
dc.contributor.author | Liu S.-K. | en_US |
dc.contributor.author | TZUNG-JENG HWANG | en_US |
dc.contributor.author | MING-HSIEN HSIEH | en_US |
dc.contributor.author | Ouyang W.-C. | en_US |
dc.contributor.author | Chan H.-Y. | en_US |
dc.contributor.author | Chen J.-J. | en_US |
dc.contributor.author | Yang W.-C. | en_US |
dc.contributor.author | Lin C.-Y. | en_US |
dc.contributor.author | Lee S.F.C. | en_US |
dc.contributor.author | Hwu H.-G. | en_US |
dc.creator | Liu Y.-L.;Fann C.S.-J.;Liu C.-M.;Chen W.J.;Wu J.-Y.;Hung S.-I.;Chen C.-H.;Jou Y.-S.;Liu S.-K.;Hwang T.-J.;Ming-Hsien Hsieh;Ouyang W.-C.;Chan H.-Y.;Chen J.-J.;Yang W.-C.;Lin C.-Y.;Lee S.F.C.;Hwu H.-G. | - |
dc.date.accessioned | 2020-03-17T06:23:01Z | - |
dc.date.available | 2020-03-17T06:23:01Z | - |
dc.date.issued | 2006 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/476445 | - |
dc.description.abstract | Background: The marker D1S251 of chromosome 1q42.1 showed significant association with schizophrenia in a Taiwanese sample. We used single nucleotide polymorphism (SNP) fine mapping to search for the vulnerability genes of schizophrenia. Methods: We selected 120 SNPs covering 1 Mb around D1S251 from the public database. These selected SNPs were initially validated if allele frequency was >10%. Forty-seven validated SNPs were genotyped in 102 families with at least 2 siblings affected with schizophrenia. Results: Two SNP blocks showed significant association with schizophrenia. Block 1 (five-SNP), located between intron 2 and intron 13 of the glyceronephosphate O-acyltransferase (GNPAT) gene, showed the most significant associations using single-locus TDT (z = -2.07, p = .038, df = 1) and haplotype association analyses (z = -1.99, p = .046, df = 1). Block 2 (two-SNP), located between intron 4 and intron 5 of the disrupted-in-schizophrenia 1 (DISC1) gene, also showed the most significant results in both the single-locus (z = -3.22, p = .0013, df = 1) and haplotype association analyses (z = 3.35, p = .0008, df = 1). The association of the DISC1 gene with schizophrenia was mainly in the patient group with sustained attention deficits as assessed by the Continuous Performance Test. Conclusions: Chromosome 1q42.1 harbors GNPAT and DISC1 as candidate genes for schizophrenia, and DISC1 is associated with sustained attention deficits. ? 2006 Society of Biological Psychiatry. | - |
dc.relation.ispartof | Biological Psychiatry | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | disrupted in schizophrenia 1 protein; gene product; glyceronephosphate o acyltransferase; protein; unclassified drug; article; attention disturbance; chromosome 1q; chromosome analysis; cognitive defect; controlled study; female; gene frequency; gene identification; gene locus; gene mapping; genetic association; genetic risk; genetic susceptibility; genotype; haplotype; human; intron; major clinical study; male; neuropsychological test; priority journal; protein determination; protein expression; schizophrenia; sibling; single nucleotide polymorphism; Acyltransferases; Attention; Chromosome Mapping; Chromosomes, Human, Pair 1; Family Health; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Linkage Disequilibrium; Male; Nerve Tissue Proteins; Neuropsychological Tests; Polymorphism, Single Nucleotide; Schizophrenia | - |
dc.title | A Single Nucleotide Polymorphism Fine Mapping Study of Chromosome 1q42.1 Reveals the Vulnerability Genes for Schizophrenia, GNPAT and DISC1: Association with Impairment of Sustained Attention | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.biopsych.2006.04.024 | - |
dc.identifier.pmid | 16997000 | - |
dc.identifier.scopus | 2-s2.0-33748741474 | - |
dc.relation.pages | 554-562 | - |
dc.relation.journalvolume | 60 | - |
dc.relation.journalissue | 6 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | Public Health | - |
crisitem.author.dept | Brain and Mind Sciences | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Brain and Mind Sciences | - |
crisitem.author.dept | Neurobiology and Cognitive Science Center | - |
crisitem.author.dept | Center for Integrated Dementia Care | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.orcid | 0000-0001-5899-5870 | - |
crisitem.author.orcid | 0000-0001-7894-9484 | - |
crisitem.author.orcid | 0000-0002-3585-7843 | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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