https://scholars.lib.ntu.edu.tw/handle/123456789/476445
標題: | A Single Nucleotide Polymorphism Fine Mapping Study of Chromosome 1q42.1 Reveals the Vulnerability Genes for Schizophrenia, GNPAT and DISC1: Association with Impairment of Sustained Attention | 作者: | Liu Y.-L. Fann C.S.-J. Liu C.-M. WEI J. CHEN Wu J.-Y. Hung S.-I. Chen C.-H. Jou Y.-S. Liu S.-K. TZUNG-JENG HWANG MING-HSIEN HSIEH Ouyang W.-C. Chan H.-Y. Chen J.-J. Yang W.-C. Lin C.-Y. Lee S.F.C. Hwu H.-G. |
公開日期: | 2006 | 卷: | 60 | 期: | 6 | 起(迄)頁: | 554-562 | 來源出版物: | Biological Psychiatry | 摘要: | Background: The marker D1S251 of chromosome 1q42.1 showed significant association with schizophrenia in a Taiwanese sample. We used single nucleotide polymorphism (SNP) fine mapping to search for the vulnerability genes of schizophrenia. Methods: We selected 120 SNPs covering 1 Mb around D1S251 from the public database. These selected SNPs were initially validated if allele frequency was >10%. Forty-seven validated SNPs were genotyped in 102 families with at least 2 siblings affected with schizophrenia. Results: Two SNP blocks showed significant association with schizophrenia. Block 1 (five-SNP), located between intron 2 and intron 13 of the glyceronephosphate O-acyltransferase (GNPAT) gene, showed the most significant associations using single-locus TDT (z = -2.07, p = .038, df = 1) and haplotype association analyses (z = -1.99, p = .046, df = 1). Block 2 (two-SNP), located between intron 4 and intron 5 of the disrupted-in-schizophrenia 1 (DISC1) gene, also showed the most significant results in both the single-locus (z = -3.22, p = .0013, df = 1) and haplotype association analyses (z = 3.35, p = .0008, df = 1). The association of the DISC1 gene with schizophrenia was mainly in the patient group with sustained attention deficits as assessed by the Continuous Performance Test. Conclusions: Chromosome 1q42.1 harbors GNPAT and DISC1 as candidate genes for schizophrenia, and DISC1 is associated with sustained attention deficits. ? 2006 Society of Biological Psychiatry. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/476445 | DOI: | 10.1016/j.biopsych.2006.04.024 | SDG/關鍵字: | disrupted in schizophrenia 1 protein; gene product; glyceronephosphate o acyltransferase; protein; unclassified drug; article; attention disturbance; chromosome 1q; chromosome analysis; cognitive defect; controlled study; female; gene frequency; gene identification; gene locus; gene mapping; genetic association; genetic risk; genetic susceptibility; genotype; haplotype; human; intron; major clinical study; male; neuropsychological test; priority journal; protein determination; protein expression; schizophrenia; sibling; single nucleotide polymorphism; Acyltransferases; Attention; Chromosome Mapping; Chromosomes, Human, Pair 1; Family Health; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Linkage Disequilibrium; Male; Nerve Tissue Proteins; Neuropsychological Tests; Polymorphism, Single Nucleotide; Schizophrenia |
顯示於: | 醫學系 |
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