|Title:||Complication rates after chorionic villus sampling and midtrimester amniocentesis: A 7-year national registry study||Authors:||Hsu W.-W.
|Issue Date:||2019||Publisher:||Elsevier B.V.||Journal Volume:||118||Journal Issue:||7||Start page/Pages:||1107-1113||Source:||Journal of the Formosan Medical Association||Abstract:||
Purpose: To assess the complication rates following chorionic villus sampling (CVS) and midtrimester amniocentesis in Taiwan. Methods: This is a national registry-based cohort study from Taiwan. We included all women with singleton pregnancies who received either CVS (n = 1409) or midtrimester amniocentesis (n = 250,566) during 2006–2012. We assessed preterm premature rupture of membranes (PPROM), intrauterine fetal demise (IUFD), infection and spontaneous abortion (SA) that occurred within fourteen days after the procedures. We also assessed the risks of preterm delivery and miscarriage before 24 gestational weeks after amniocentesis. These complications were collected from the Genetic Disease Database of the Ministry of Health and Welfare, Taiwan National Birth Certificate Registry, and the Taiwan National Health Insurance Database. Pearson χ2 tests were used to compare the distributions between groups. Results: For patients who underwent midtrimester amniocentesis, the rates of PPROM, IUFD, infection and SA within fourteen days were 0.24%, 0.11%, 0.05%, and 0.05%, respectively. Women with a normal fetal karyotype had a preterm birth rate (<37 gestational weeks) of 9.38%. The miscarriage rate (<24 gestational weeks) was 0.68%, which was 0.22% higher than those who did not receive the invasive procedures (p < 0.0001). After CVS, the IUFD rate was 1.68%, and the SA rate within fourteen days was 0.77%. Conclusion: The use of our large cohort demonstrated that the procedure-related complication rates were comparable to recent review or meta-analysis. This dataset might facilitate counselling in women who consider invasive genetic diagnostic procedures. ? 2019
|ISSN:||0929-6646||DOI:||10.1016/j.jfma.2019.03.006||metadata.dc.subject.other:||adult; amniocentesis; Article; chorion villus sampling; cohort analysis; controlled study; female; fetus death; gestational age; hemophilia; human; iatrogenic disease; infection; invasive procedure; karyotype; low birth weight; major clinical study; maternal age; population research; pregnant woman; premature fetus membrane rupture; premature labor; prenatal diagnosis; second trimester pregnancy; spinal muscular atrophy; spontaneous abortion; Taiwan; thalassemia; treatment indication; adverse event; amniocentesis; chorion villus sampling; labor complication; pregnancy; premature fetus membrane rupture; prematurity; register; risk factor; second trimester pregnancy; spontaneous abortion; Abortion, Spontaneous; Adult; Amniocentesis; Chorionic Villi Sampling; Female; Fetal Membranes, Premature Rupture; Gestational Age; Humans; Obstetric Labor Complications; Pregnancy; Pregnancy Trimester, Second; Premature Birth; Registries; Risk Factors; Taiwan
|Appears in Collections:||醫學系|
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