https://scholars.lib.ntu.edu.tw/handle/123456789/477506
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | MING-TSAN LIN | en_US |
dc.contributor.author | Kung S.-P. | en_US |
dc.contributor.author | Yeh S.-L. | en_US |
dc.contributor.author | Liaw K.-Y. | en_US |
dc.contributor.author | Wang M.-Y. | en_US |
dc.contributor.author | Kuo M.-L. | en_US |
dc.contributor.author | PO-HUANG LEE | en_US |
dc.contributor.author | Chen W.-J. | en_US |
dc.creator | Ming-Tsan Lin;Kung S.-P.;Yeh S.-L.;Liaw K.-Y.;Wang M.-Y.;Kuo M.-L.;Lee P.-H.;Chen W.-J. | - |
dc.date.accessioned | 2020-03-23T04:01:09Z | - |
dc.date.available | 2020-03-23T04:01:09Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-30644469266&doi=10.3748%2fwjg.v11.i39.6197&partnerID=40&md5=c470d0bb779bcb85f97c0531917848a5 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/477506 | - |
dc.description.abstract | Aim: To evaluate whether the effect of Gln dipeptide-enriched total parenteral nutrition (TPN) on postoperative cytokine alteration depended on the disease severity of surgical patients. Methods: Forty-eight patients with major abdominal surgery were allocated to two groups to receive isonitrogenous (0.228 g nitrogen/kg per d) and isocaloric (30 kcal/kg per d) TPN for 6 d. Control group (Conv) using conventional TPN solution received 1.5 g amino acids/kg per day, whereas the test group received 0.972 g amino acids/kg per day and 0.417 g L-alanyl-L-glutamine (Ala-Gln)/kg per day. Blood samples were collected on d 1 and d 6 postoperatively for plasma interleukin (IL)-2, IL-6, IL-8, and interferon (IFN)-γ analysis. Results: Plasma IL-2 and IFN-γ were not detectable. IL-6 concentrations were significantly lower on the 6th postoperative day in the Ala-Gln group than those in the Conv group in patients with APACHE II?6, whereas no difference was noted in patients with APACHE II>6. There was no difference in IL-8 levels between the two groups. No difference in cumulative nitrogen balance was observed on d 2-5 after the operation between the two groups (Ala-Gln -3.2±1.6 g vs Conv -6.5±2.7 g). A significant inverse correlation was noted between plasma IL-6 levels and cumulative nitrogen balance postoperatively in the Ala-Gln group, whereas no such correlation was observed in the Conv group. Conclusion: TPN supplemented with Gin dipeptide had no effect on plasma IL-8 levels after surgery. However, Gln supplementation had a beneficial effect on decreasing systemic IL-6 production after surgery in patients with low admission illness severity, and lower plasma IL-6 may improve nitrogen balance in patients with abdominal surgery when Gln was administered. ? 2005 The WJG Press and Elsevier Inc. All rights reserved. | - |
dc.publisher | WJG Press | - |
dc.relation.ispartof | World Journal of Gastroenterology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | alanylglutamine; amino acid; gamma interferon; interleukin 2; interleukin 6; interleukin 8; nitrogen; abdominal surgery; adult; aged; article; blood sampling; caloric intake; clinical article; clinical trial; colon cancer; controlled clinical trial; controlled study; correlation analysis; cytokine production; disease severity; double blind procedure; duodenum cancer; enzyme linked immunosorbent assay; female; hospitalization; human; liver cell carcinoma; male; multicenter study; nitrogen balance; nutritional support; pancreas cancer; parallel design; postoperative care; postoperative complication; postoperative period; protein blood level; randomized controlled trial; rectum cancer; side effect; stomach cancer; total parenteral nutrition | - |
dc.title | Glutamine-supplemented total parenteral nutrition attenuates plasma interleukin-6 in surgical patients with lower disease severity | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.3748/wjg.v11.i39.6197 | - |
dc.identifier.pmid | 16273650 | - |
dc.identifier.scopus | 2-s2.0-30644469266 | - |
dc.relation.pages | 6197-6201 | - |
dc.relation.journalvolume | 11 | - |
dc.relation.journalissue | 39 | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.orcid | 0000-0001-7313-7057 | - |
crisitem.author.orcid | 0000-0001-5831-035X | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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