https://scholars.lib.ntu.edu.tw/handle/123456789/477782
Title: | Common genetic determinants of breast-cancer risk in east asian women: A collaborative study of 23 637 breast cancer cases and 25 579 controls | Authors: | Zheng W. Zhang B. Cai Q. Sung H. Michailidou K. Shi J. Choi J.-Y. Long J. Dennis J. Humphreys M.K. Wang Q. Lu W. Gao Y.-T. Li C. Cai H. Park S.K. Yoo K.-Y. Noh D.-Y. Han W. Dunning A.M. Benitez J. Vincent D. Bacot F. Tessier D. Kim S.-W. Lee M.H, Lee J.W, Lee J.-Y. Xiang Y.-B. Zheng Y. Wang W. Ji B.-T. Matsuo K. Ito H. Iwata H. Tanaka H. Wu A.H. Tseng C.-C. Van Den Berg D. Stram D.O. Teo S.H, Yip C.H, Kang I.N, Wong T.Y. Shen C.-Y. Yu J.-C. CHIUN-SHENG HUANG Hou M.-F. Hartman M. Miao H. Lee S.C, Putti T.C, Muir K. Lophatananon A. Stewart-Brown S. Siriwanarangsan P. Sangrajrang S. Shen H. Chen K. Wu P.-E. Ren Z. Haiman C.A. Sueta A. Kim M.K, Khoo U.S, Iwasaki M. Pharoah P.D.P. Wen W. Hall P. Shu X.-O. Easton D.F. Kang D. |
Issue Date: | 2013 | Journal Volume: | 22 | Journal Issue: | 12 | Start page/Pages: | 2539-2550 | Source: | Human Molecular Genetics | Abstract: | In a consortium including 23 637 breast cancer patients and 25 579 controls of East Asian ancestry, we investigated70 single-nucleotide polymorphisms (SNPs) in 67 independent breast cancer susceptibility loci recently identified by genome-wide association studies (GWASs) conducted primarily in European-ancestry populations. SNPs in 31 loci showed an association with breast cancer risk at P < 0.05 in a direction consistent with that reported previously. Twenty-one of them remained statistically significant after adjusting for multiple comparisons with the Bonferroni-corrected significance level of <0.0015. Eight of the 70 SNPs showed a significantly different association with breast cancer risk by estrogen receptor (ER) status at P < 0.05. With the exception of rs2046210 at 6q25.1, the seven other SNPs showed a stronger association with ER-positive than ER-negative cancer. This study replicated all five genetic risk variants initially identified in Asians and provided evidence for associations of breast cancer risk in the East Asian population with nearly half of the genetic risk variants initially reported in GWASs conducted in European descendants. Taken together, these common genetic risk variants explain ~10% of excess familial risk of breast cancer in Asian populations. ? The Author 2013. Published by Oxford University Press. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84878508496&doi=10.1093%2fhmg%2fddt089&partnerID=40&md5=f0a5ae8e2a646c317b7c5de8314e8c30 https://scholars.lib.ntu.edu.tw/handle/123456789/477782 |
ISSN: | 0964-6906 | DOI: | 10.1093/hmg/ddt089 | SDG/Keyword: | estrogen receptor; article; Asian; breast cancer; cancer patient; cancer risk; Caucasian; controlled study; familial cancer; female; gene locus; genetic analysis; genome analysis; human; major clinical study; priority journal; single nucleotide polymorphism; Adult; Aged; Asian Continental Ancestry Group; Breast Neoplasms; Case-Control Studies; China; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Middle Aged; Polymorphism, Single Nucleotide; Receptors, Estrogen; Republic of Korea |
Appears in Collections: | 醫學系 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.