|dc.creator||CHIEN-CHANG LEE;Chang S.-S.;Hsu S.-C.;Tsai Y.-W.;Lee S.-H.;Lee S.-H.;Gabriel M.-T.;Wu J.-Y.||-|
|dc.description.abstract||Numerous epidemiological data suggest that the use of angiotensin-converting enzyme inhibitors (ACEis) can improve the clinical outcomes of pneumonia. Tuberculosis (TB) is an airborne bacteria like pneumonia, and we aimed to find out whether the use of ACEis can decrease the risk of active TB. We conducted a nested case-control analysis by using a 1 million longitudinally followed cohort, from Taiwan national health insurance research database. The rate ratios (RRs) for TB were estimated by conditional logistic regression, and adjusted using a TB-specific disease risk score (DRS) with 71 TB-related covariates. From January, 1997 to December, 2011, a total of 75,536 users of ACEis, and 7720 cases of new active TB were identified. Current use (DRS adjusted RR, 0.87 [95% CI, 0.78-0.97]), but not recent and past use of ACEis, was associated with a decrease in risk of active TB. Interestingly, it was found that chronic use (>90 days) of ACEis was associated with a further decrease in the risk of TB (aRR, 0.74, [95% CI, 0.66-0.83]). There was also a duration response effect, correlating decrease in TB risk with longer duration of ACEis use. The decrease in TB risk was also consistent across all patient subgroups (age, sex, heart failure, cerebrovascular diseases, myocardial infraction, renal diseases, and diabetes) and patients receiving other cardiovascular medicine. In this large population-based study, we found that subjects with recent and chronic use of ACEis were associated with decrease in TB risk. Copyright ? 2016 Wolters Kluwer Health, Inc. All rights reserved.||-|
|dc.relation.ispartof||Medicine (United States)||-|
|dc.subject.other||acetylsalicylic acid; benazepril; beta adrenergic receptor blocking agent; calcium channel blocking agent; candesartan; captopril; cilazapril; digoxin; dipeptidyl carboxypeptidase inhibitor; enalapril; eprosartan; fosinopril; hydroxymethylglutaryl coenzyme A reductase inhibitor; irbesartan; lisinopril; loop diuretic agent; losartan; nitric acid derivative; olmesartan; perindopril; quinapril; ramipril; telmisartan; urinary tract agent; valsartan; dipeptidyl carboxypeptidase inhibitor; adult; aged; Article; cardiovascular disease; chronic drug administration; comorbidity; controlled study; disease association; female; human; infection prevention; infection risk; kidney disease; longitudinal study; major clinical study; male; population based case control study; prescription; priority journal; Taiwan; tuberculosis; case control study; factual database; post exposure prophylaxis; procedures; risk assessment; risk factor; statistical model; time factor; Tuberculosis, Pulmonary; Angiotensin-Converting Enzyme Inhibitors; Case-Control Studies; Databases, Factual; Female; Humans; Logistic Models; Longitudinal Studies; Male; Post-Exposure Prophylaxis; Risk Assessment; Risk Factors; Taiwan; Time Factors; Tuberculosis, Pulmonary||-|
|dc.title||Angiotensin-converting enzyme inhibitors and active tuberculosis: A population-based study||en_US|
|Appears in Collections:||醫學院附設醫院 (臺大醫院)|
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