https://scholars.lib.ntu.edu.tw/handle/123456789/478410
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | WEN-HUNG KUO | en_US |
dc.contributor.author | CHIEN-AN YAO | en_US |
dc.contributor.author | Lin C.H. | en_US |
dc.contributor.author | KING-JEN CHANG | en_US |
dc.creator | Wen-Hung Kuo;Yao C.-A.;Lin C.H.;Chang K.-J. | - |
dc.date.accessioned | 2020-03-24T04:02:52Z | - |
dc.date.available | 2020-03-24T04:02:52Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1741-427X | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84861059890&doi=10.1155%2f2012%2f803239&partnerID=40&md5=487c32c0164c68470cf12b8e46a90dfe | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/478410 | - |
dc.description.abstract | To evaluate the safety and efficacy of Tien-Hsien Liquid Practical (THL-P), a Chinese herbal mixture, in patients with refractory metastatic breast cancer, we performed a randomized, double-blind, placebo-controlled, parallel-group, phase IIa pilot trial. Patients were randomly assigned to either receive THL-P or matching placebo and followed up every 4 weeks for 24 weeks. The primary endpoint was changes in the global health status/quality of life (GHS/QOL) scale. The secondary endpoints were changes in functional and symptom scales, immunomodulating effects, and adverse events. Sixty-three patients were enrolled between June 2009 and June 2011. The intent-to-treat population included 28 patients in the THL-P group and 11 patients in the placebo group. Compared to the placebo group, the THL-P group had significant improvement from baseline to last visit in GHS/QOL (41.7 versus 33.3; P < 0.05), CD3, CD4/CD8, CD19, CD16+56 positive cells (P < 0.05), and higher levels of physical, role, emotional, and cognitive functioning, as well as decreased fatigue and systemic side effects. Treatment-related adverse events were mild constipation and localized itching, and no serious adverse events were reported. THL-P appears to be a safe alternative adjuvant treatment for patients with refractory metastatic breast cancer, as it effectively improves QOL and palliates cancer-related symptoms. Copyright ? 2012 Wen-Hung Kuo et al. | - |
dc.relation.ispartof | Evidence-based Complementary and Alternative Medicine | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | CD16 antigen; CD19 antigen; CD3 antigen; CD4 antigen; CD8 antigen; herbaceous agent; tien hsien liquid practical; unclassified drug; adult; aged; article; breast metastasis; Chinese medicine; cognition; constipation; controlled study; double blind procedure; drug efficacy; drug safety; emotion; fatigue; female; follow up; health status; human; immunomodulation; intention to treat analysis; major clinical study; phase 2 clinical trial; physical activity; priority journal; pruritus; quality of life; refractory metastatic breast cancer | - |
dc.title | Safety and efficacy of Tien-Hsien Liquid Practical in patients with refractory metastatic breast cancer: A randomized, double-blind, placebo-controlled, parallel-group, phase IIa trial | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1155/2012/803239 | - |
dc.identifier.scopus | 2-s2.0-84861059890 | - |
dc.relation.pages | 803239 | - |
dc.relation.journalvolume | 2012 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Family Medicine | - |
crisitem.author.dept | Family Medicine-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.orcid | 0000-0002-9881-4605 | - |
crisitem.author.orcid | 0000-0001-8074-6379 | - |
crisitem.author.orcid | 0000-0001-9811-3422 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。