https://scholars.lib.ntu.edu.tw/handle/123456789/478618
Title: | High peritoneal KT/V and peritonitis rates are associated with peritoneal calcification. | Authors: | JENQ-WEN HUANG Lien Y.C. Yang C.Y. KAO-LANG LIU CHENG-CHUNG FANG CHO-KAI WU JEN-KUANG LEE Wu H.Y. CHIH-KANG CHIANG HUI-TENG CHENG CHUNG-JEN YEN KUAN-YU HUNG |
Issue Date: | 2013 | Journal Volume: | 8 | Journal Issue: | 8 | Start page/Pages: | e71636 | Source: | PloS one | Abstract: | Peritoneal calcification (PC) is a specific finding in patients undergoing peritoneal dialysis (PD), but its prevalence, risk factors, and impacts in PD patients remain unclear. The present study investigated these issues and provided information useful for the management of PC. The study included 183 PD patients. The severity of PC was determined using abdominal computed tomography (CT), and we summed up all scores from slices obtained from the diaphragm to the pelvic floor normalized to body surface area. We analyzed the associations between PC and demographic and clinical characteristics, and between PC and levels of biomarkers, including C-reactive protein (CRP), osteoprotegrin and fetuin-A. The determinants of PC were examined using multiple regression analysis. Patients were categorized into group 1 (without PC, n = 133) and group 2 (with PC, n = 50). Group 2 patients showed different degrees of PC with a mean of 160±769 mm(2)/m(2). Group 1 patients had higher fetuin-A levels than group 2 patients (861±309 vs. 760±210 μg/mL; p = 0.021). The independent risk factors for the presence of PC included male gender, previous peritonitis, and PD adequacy (KT/V). Further analysis performed in group 2 patients showed that the dosage of vitamin D, serum levels of CRP, and dialysate calcium load were the independent determinants of PC. However, the presence of PC did not affect patients' technique survival, peritonitis incidence, or mortality in the mean follow up period of 28±12 months. The presence and severity of PC were associated with inflammation, peritoneal KT/V, and mineral metabolism. The impact of PC on the outcomes of PD patients requires further study with a longer follow-up. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/478618 | ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0071636 | SDG/Keyword: | calcinosis; complication; computer assisted tomography; female; human; Kaplan Meier method; male; middle aged; pathology; peritoneal dialysis; peritoneum; peritonitis; radiography; statistical model; treatment outcome; Calcinosis; Female; Humans; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Peritoneal Dialysis; Peritoneum; Peritonitis; Tomography, X-Ray Computed; Treatment Outcome |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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