https://scholars.lib.ntu.edu.tw/handle/123456789/479338
DC Field | Value | Language |
---|---|---|
dc.contributor.author | ANG YUAN | en_US |
dc.contributor.author | CHONG-JEN YU | en_US |
dc.contributor.author | KWEN-TAY LUH | en_US |
dc.contributor.author | Kuo S.-H. | en_US |
dc.contributor.author | Lee Y.-C. | en_US |
dc.contributor.author | PAN-CHYR YANG | en_US |
dc.creator | Ang Yuan;Yu C.-J.;Luh K.-T.;Kuo S.-H.;Lee Y.-C.;Yang P.-C. | - |
dc.date.accessioned | 2020-03-26T06:54:32Z | - |
dc.date.available | 2020-03-26T06:54:32Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0732-183X | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/479338 | - |
dc.description.abstract | Purpose: To evaluate interactions between expressions of tumor suppressor gene p53 and angiogenic factors vascular endothelial cell growth factor (VEGF) and interleukin-8 (IL-8) and their effect on tumor angiogenesis and patient prognosis in non-small-cell lung cancer (NSCLC). Patients and Methods: p53, VEGF, IL-8, and the microvessel endothelium were immunostained, and VEGF and IL-8 mRNA expression were quantified using the real-time quantitative reverse-transcription polymerase chain reaction in 65 NSCLC surgical specimens. Aberrant p53 expression was correlated with VEGF and IL-8 mRNA expression, microvessel count (MVC), other clinical-pathologic variables, and patients' survival. Results: Tumors with high aberrant p53 expression showed significantly higher VEGF and IL-8 mRNA expression and MVC than those with low aberrant p53 expression (P < .001). When tested as a continuous variable, aberrant p53 expression correlated strongly and positively with VEGF and IL-8 mRNA expression and MVC (P < .0001). Tumors with high aberrant p53 expression were associated with mediastinal or distant lymph node metastasis (P = .006). Survival and postoperative relapse time were significantly shorter in patients with high aberrant p53 expression tumors than in those with low aberrant expression tumors (P < .0001). A significant difference in survival was also seen between patients with high and low tumoral VEGF mRNA expression and between those with high and low tumoral IL-8 mRNA expression (P < .0001). Conclusion: We report here for the first time that aberrant p53 expression is strongly positively correlated with VEGF mRNA and IL-8 mRNA expression in NSCLC. This result indicates that aberrant p53 expression may play a significant role in regulation of VEGF and IL-8 expression and be involved in controlling angiogenesis and explains the adverse prognosis of cancers with high aberrant p53 expression. ? 2002 by American Society of Clinical Oncology. | - |
dc.relation.ispartof | Journal of Clinical Oncology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | interleukin 8; messenger RNA; protein p53; vasculotropin; adult; aged; angiogenesis; article; cancer inhibition; cancer survival; controlled study; disease association; endothelium; female; human; human tissue; immunohistochemistry; lung non small cell cancer; lymph node metastasis; major clinical study; male; mediastinum metastasis; microvasculature; priority journal; prognosis; protein expression; protein interaction; reverse transcription polymerase chain reaction; tumor suppressor gene; Adult; Aged; Carcinoma, Non-Small-Cell Lung; DNA, Neoplasm; Endothelial Growth Factors; Female; Gene Expression Regulation, Neoplastic; Genes, p53; Humans; Immunohistochemistry; Interleukin-8; Lung Neoplasms; Lymphokines; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neovascularization, Pathologic; Prognosis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Analysis; Tumor Suppressor Protein p53; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | - |
dc.title | Aberrant p53 expression correlates with expression of vascular endothelial growth factor mRNA and interleukin-8 mRNA and neoangiogenesis in non-small-cell lung cancer | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1200/JCO.20.4.900 | - |
dc.identifier.pmid | 11844810 | - |
dc.identifier.scopus | 2-s2.0-0037083324 | - |
dc.relation.pages | 900-910 | - |
dc.relation.journalvolume | 20 | - |
dc.relation.journalissue | 4 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Emergency Medicine | - |
crisitem.author.dept | Emergency Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | National Taiwan University Hospital Hsin-Chu Branch | - |
crisitem.author.dept | NTU BioMedical Park Hospital | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Oncology | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-5664-1339 | - |
crisitem.author.orcid | 0000-0001-5664-9392 | - |
crisitem.author.orcid | 0000-0001-6330-6048 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital Hsin-Chu Branch | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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