https://scholars.lib.ntu.edu.tw/handle/123456789/479637
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | LU-TING KUO | en_US |
dc.contributor.author | KUAN-TING KUO | en_US |
dc.contributor.author | Lee M.-J. | en_US |
dc.contributor.author | Wei C.-C. | en_US |
dc.contributor.author | Scaravilli F. | en_US |
dc.contributor.author | JUI-CHANG TSAI | en_US |
dc.contributor.author | Tseng H.-M. | en_US |
dc.contributor.author | MENG-FAI KUO | en_US |
dc.contributor.author | YONG-KWANG TU | en_US |
dc.creator | Tu Y.-K.;Kuo M.-F.;Tseng H.-M.;Tsai J.-C.;Scaravilli F.;Wei C.-C.;Lee M.-J.;Kuo K.-T.;LU-TING KUO | - |
dc.date.accessioned | 2020-03-27T02:23:28Z | - |
dc.date.available | 2020-03-27T02:23:28Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0020-7136 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-65649087830&doi=10.1002%2fijc.24303&partnerID=40&md5=9a1ea72419d45b14c389001649c1bf27 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/479637 | - |
dc.description.abstract | Recent studies have revealed a correlation between specific genetic changes, such as loss of chromosome 1p and 19q, and sensitivity of oligodendroglial neoplasm to radiotherapy and chemotherapy; epigenetic changes also play an important role in some tumors. In this retrospective study, we analyzed chromosomal alterations in 17 loci and promoter methylation status of 8 tumor-related genes in 49 oligodendroglial tumors (29 WHO grade II and 11 WHO grade III oligodendrogliomas; 7 WHO grade II and 2 WHO grade III oligoastrocytomas) using quantitative microsatellite analysis and methylation-specific polymerase chain reaction and correlated this information with clinical data. We also performed immunohistochemical stains for Ki-67 and O (6)-methyl guanine-DNA methyl transferase. Our results showed that the frequency of deletions in regions on 1p, 9p, 10q, 17p and 19q were 71.4%, 26.5%, 6.1%, 69.4% and 89.8%, respectively. Promoter methylation was detected in p14, p15, p16, p53, p73, PTEN, MGMT and RASSF1A genes in 24.5%, 6.1%, 46.9%, 0%, 6.1%, 42.9%, 53.1% and 77.6% of tumors, respectively. Statistical analysis identified that 9p22 loss, p73 methylation and p15 methylation were independently associated with reduced overall survival, and Ki-67 labeling index (LI) ? 5%, 9p22 loss, no loss of 19q, p73 methylation, p14 methylation and unmethylated MGMT predicted shorter progression-free survival. Our findings suggest that the frequent deletion and hypermethylation of tumor-related genes may represent a mechanism of tumor development and progression and emphasize the importance of defining new molecular markers for predicting prognosis, tumor recurrence and therapeutic response in cancer management. ? 2009 UICC. | - |
dc.relation.ispartof | International Journal of Cancer | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Ki 67 antigen; lomustine; methylated DNA protein cysteine methyltransferase; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; procarbazine; protein p14; protein p15; protein p16; protein p53; protein p73; Ras association domain family protein 1A; vincristine; DNA; DNA methyltransferase; Ki 67 antigen; MGMT protein, human; MIB1 protein, human; microsatellite DNA; polydeoxyribonucleotide synthase; tumor protein; tumor suppressor protein; ubiquitin protein ligase; adolescent; adult; aged; article; astrocytoma; cancer chemotherapy; cancer radiotherapy; cancer survival; child; chromosome 10q; chromosome 17p; chromosome 19q; chromosome 1p; chromosome 9p; chromosome deletion; clinical article; clinical feature; controlled study; DNA hypermethylation; DNA methylation; epigenetics; female; gene locus; glioblastoma; histopathology; human; human tissue; labeling index; male; microsatellite marker; oligodendroglioma; oncogene; overall survival; preschool child; priority journal; progression free survival; promoter region; school child; brain tumor; cancer staging; cell proliferation; chromosome aberration; enzyme immunoassay; genetic epigenesis; genetics; human chromosome; metabolism; middle aged; oligodendroglioma; pathology; polymerase chain reaction; retrospective study; survival rate; Adolescent; Adult; Aged; Aged, 80 and over; Brain Neoplasms; Cell Proliferation; Child; Child, Preschool; Chromosome Aberrations; Chromosomes, Human; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; DNA, Neoplasm; Epigenesis, Genetic; Female; Humans; Immunoenzyme Techniques; Ki-67 Antigen; Male; Microsatellite Repeats; Middle Aged; Neoplasm Proteins; Neoplasm Staging; Oligodendroglioma; Polymerase Chain Reaction; Promoter Regions, Genetic; Retrospective Studies; Survival Rate; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Young Adult | - |
dc.title | Correlation among pathology, genetic and epigenetic profiles, and clinical outcome in oligodendroglial tumors | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/ijc.24303 | - |
dc.identifier.pmid | 19330828 | - |
dc.identifier.scopus | 2-s2.0-65649087830 | - |
dc.relation.pages | 2872-2879 | - |
dc.relation.journalvolume | 124 | - |
dc.relation.journalissue | 12 | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.orcid | 0000-0002-1405-8700 | - |
crisitem.author.orcid | 0000-0002-3657-1652 | - |
crisitem.author.orcid | 0000-0003-2723-6841 | - |
crisitem.author.orcid | 0000-0002-1803-2719 | - |
crisitem.author.orcid | 0000-0003-2113-1176 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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