https://scholars.lib.ntu.edu.tw/handle/123456789/479833
標題: | Clinical characteristics and treatment outcomes of patients with candidaemia due to Candida parapsilosis sensu lato species at a medical centre in Taiwan, 2000-12 | 作者: | Chen, Chien-Yuan WANG-HUEI SHENG Huang S.-Y. WEN-CHIEN CHOU MING YAO JIH-LUH TANG WOEI TSAY HWEI-FANG TIEN PO-REN HSUEH |
公開日期: | 2014 | 卷: | 70 | 期: | 5 | 起(迄)頁: | 1531-1538 | 來源出版物: | Journal of Antimicrobial Chemotherapy | 摘要: | Objectives: To investigate the clinical characteristics and treatment outcomes of adult patients with Candida parapsilosis sensu lato candidaemia. Methods:We evaluated data in themycology database of the National Taiwan University Hospital and on patients diagnosed with candidaemia due to C. parapsilosis sensu lato species from 2000 to 2012. Isolates were identified to the species level by conventional identification methods, MALDI-TOF and gene sequencing analysis. Results: A total of 323 adult patients with candidaemia caused by C. parapsilosis sensu lato species were evaluated, including 256 (79.3%) patients with C. parapsilosis sensu stricto, 34 (10.5%) with Candida orthopsilosis and 33 (10.2%) with Candidametapsilosis. Therewere 222menand 101womenand themedian agewas 60 years (range 18-103 years). Among them, 178 (55%) had an underlying diagnosis of cancer. The overall 30 day mortality rate was 25% (n1/480). Multivariate analysis revealed that shock (P,0.001), antifungal therapy (P1/40.002), central catheter removal (P1/40.02) and abdominal surgery (P1/40.043) were independent prognostic factors for patients with candidaemia due to C. parapsilosis sensu lato species. There were no significant differences in 30 day mortality rate among patients with candidaemia caused by the three different species (P1/40.770). All isolates of C. metapsilosis, C. orthopsilosis and C. parapsilosis sensu stricto were susceptible to voriconazole. WT isolates were susceptible to itraconazole, posaconazole and amphotericin B. Conclusions: There were no significant differences in 30 day mortality among patients with candidaemia caused by C. parapsilosis sensu stricto, C. metapsilosis or C. orthopsilosis. The currently used antifungal agents exhibited good in vitro activities against C. parapsilosis sensu lato species isolates. ? The Author 2015. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/479833 | ISSN: | 0305-7453 | DOI: | 10.1093/jac/dku540 | SDG/關鍵字: | amphotericin B; antifungal agent; fluconazole; itraconazole; micafungin; posaconazole; voriconazole; antifungal agent; abdominal surgery; adult; aged; antifungal susceptibility; Article; Candida metapsilosis; Candida orthopsilosis; Candida parapsilosis; Candida parapsilosis sensu lato; candidemia; catheter infection; catheter removal; chemotherapy; colon cancer; data base; digestive system cancer; female; gene sequence; human; leukemia; liver cell carcinoma; lung cancer; lymphoma; major clinical study; male; matrix assisted laser desorption ionization time of flight mass spectrometry; minimum inhibitory concentration; mortality; multivariate analysis; prognosis; shock; stomach cancer; Taiwan; treatment outcome; very elderly; adolescent; Candida; candidemia; classification; isolation and purification; middle aged; pathology; survival; treatment outcome; university hospital; young adult; Academic Medical Centers; Adolescent; Adult; Aged; Aged, 80 and over; Antifungal Agents; Candida; Candidemia; Female; Humans; Male; Middle Aged; Survival Analysis; Taiwan; Treatment Outcome; Young Adult |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。