https://scholars.lib.ntu.edu.tw/handle/123456789/480042
Title: | Healthcare-associated bacteraemia caused by Leuconostoc species at a university hospital in Taiwan between 1995 and 2008 | Authors: | MENG-RUI LEE YU-TSUNG HUANG PING-ING LEE Liao C.-H. Lai C.-C. LI-NA LEE PO-REN HSUEH |
Issue Date: | 2011 | Journal Volume: | 78 | Journal Issue: | 1 | Start page/Pages: | 45-49 | Source: | Journal of Hospital Infection | Abstract: | We studied twenty patients with Leuconostoc spp. bacteraemia at a tertiary hospital in northern Taiwan between 1995 and 2008. All isolates were identified to species level using conventional and commercial automated methods in conjunction with 16S rRNA sequencing analysis. Leuconostoc lactis (15/20, 75%) constituted the most common species but required molecular methods for accurate identification. Minimum inhibitory concentrations (MICs) of 10 antimicrobial agents were determined using the broth microdilution method. Among these 20 patients, 19 had healthcare-associated Leuconostoc spp. bacteraemia and 11 patients (55%) had underlying malignancies. Eleven had been hospitalised for more than 30 days (median: 32.5 days; range: 0-252 days) before the bacteraemic episode. At the time of bacteraemia, 11 had a Pitt bacteraemia score of ?4 (median: 4; range: 0-7) and 12 had a modified Acute Physiological Assessment and Chronic Health Evaluation (APACHE II) score of ?20 (median: 22; range: 5-37). Azithromycin (MIC: 0.12 μg/mL), moxifloxacin (MIC: 0.25-0.5 μg/mL), daptomycin (MIC: 0.03-0.25 μg/mL) and tigecycline (MIC: 0.06-0.12 μg/mL) exhibited good in vitro activity against Leuconostoc spp. although bacteraemia due to L. lactis was associated with high mortality in immunocompromised patients. ? 2010 The Healthcare Infection Society. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/480042 | ISSN: | 0195-6701 | DOI: | 10.1016/j.jhin.2010.11.014 | SDG/Keyword: | ampicillin; azithromycin; carbapenem; ceftobiprole; cephalosporin; cotrimoxazole; daptomycin; doripenem; linezolid; meropenem; moxifloxacin; penicillin G; polypeptide antibiotic agent; quinoline derived antiinfective agent; RNA 16S; tigecycline; vancomycin; adolescent; adult; aged; antibacterial activity; antibiotic sensitivity; APACHE; article; bacteremia; bacterium identification; bacterium isolate; broth dilution; child; clinical article; female; Gram positive infection; hospital infection; human; immune deficiency; Leuconostoc; Leuconostoc citreum; Leuconostoc mesenteroides; Leuconostoc pseudomesenteroides; leukonostoc lactis; male; minimum inhibitory concentration; mortality; neoplasm; nonhuman; nucleotide sequence; school child; species identification; Taiwan; university hospital; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteremia; Bacteriological Techniques; Child; Cross Infection; Female; Gram-Positive Bacterial Infections; Hospitals, University; Humans; Leuconostoc; Male; Microbial Sensitivity Tests; Middle Aged; Molecular Diagnostic Techniques; Risk Factors; Taiwan; Young Adult |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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