https://scholars.lib.ntu.edu.tw/handle/123456789/480071
Title: | Bacteraemia caused by Weissella confusa at a university hospital in Taiwan, 1997-2007 | Authors: | MENG-RUI LEE YU-TSUNG HUANG Liao C.-H. Lai C.-C. PING-ING LEE PO-REN HSUEH |
Issue Date: | 2011 | Journal Volume: | 17 | Journal Issue: | 8 | Start page/Pages: | 1226-1231 | Source: | Clinical Microbiology and Infection | Abstract: | Human infections caused by Weissella confusa are rarely reported. Ten patients with bacteraemia caused by W. confusa who were treated at a tertiary-care hospital in Taiwan during 1997-2007 were studied. All isolates were initially misidentified as various Lactobacillus and Leuconostoc species by two commercial automated identification methods, and were confirmed to be W. confusa by 16S rRNA sequencing analysis. MICs of these isolates for ten antimicrobial agents were determined by the agar dilution method. The characteristics of these patients included underlying malignancy (n=4), presence of a central catheter (n=6), surgery within the previous 3 months (n=4) and concomitant polymicrobial bacteraemia (n=5, 50%). Mortality was directly attributed to bacteraemia in two patients. All isolates exhibited high trimethoprim-sulphamethoxazole and ceftazidime MICs (?128mg/L) and were inhibited by linezolid, daptomycin, ceftobiprole and tigecycline at 4, 0.12, 2 and 0.12mg/L, respectively. In conclusion, W. confusa should be included in the list of organisms causing bacteraemia in immunocompromised hosts. Novel antibiotics, including daptomycin, moxifloxacin, doripenem and tigecycline, exert good activity against W. confusa. ? 2010 The Authors. Clinical Microbiology and Infection ? 2010 European Society of Clinical Microbiology and Infectious Diseases. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/480071 | ISSN: | 1198-743X | DOI: | 10.1111/j.1469-0691.2010.03388.x | SDG/Keyword: | amoxicillin plus clavulanic acid; cefepime; ceftazidime; ceftobiprole; ciprofloxacin; cotrimoxazole; daptomycin; doripenem; linezolid; piperacillin plus tazobactam; RNA 16S; sultamicillin; tigecycline; vancomycin; Acinetobacter baumannii; Acinetobacter infection; adult; agar dilution; aged; antibiotic sensitivity; antibiotic therapy; article; bacteremia; bacterium identification; blood sampling; Chryseobacterium indologenes; clinical article; Enterobacter aerogenes; Enterobacteriaceae infection; enterococcal infection; female; Gram negative infection; human; male; minimum inhibitory concentration; mortality; nonhuman; priority journal; RNA sequence; Taiwan; tertiary health care; Weissella; Weissella confusa; Weissella confusa infection; Lactobacillus; Leuconostoc; Weissella confusa |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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