https://scholars.lib.ntu.edu.tw/handle/123456789/480845
標題: | Revision in reference ranges of peripheral total leukocyte count and diffential leukocyte percentages based on a normal serum C-reactive protein level | 作者: | ZEI-SHUNG HUANG SHYH-CHYI LO WOEI TSAY Hsu K.-L. FU-TIEN CHIANG |
公開日期: | 2007 | 卷: | 106 | 期: | 8 | 起(迄)頁: | 608-616 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/Purpose: A higher total leukocyte count is a predictor of all-cause mortality and cardiovascular morbidity. The currently used reference range for peripheral total leukocyte count is wide (4.5- 11.0 × 109/L) and is associated with a low sensitivity in identifying non-infectious chronic diseases. We attempt to revise it based on a normal serum C-reactive protein (CRP) level. Methods: Study subjects were participants in a health check program at our hospital between 2000 and 2002. Those whose leukocyte analysis had been checked with the Sysmex Cell Counter NE-9000 were enrolled. Results: Significantly positive relationships between CRP level and total leukocyte count, neutrophil percentage, and monocyte percentage were found in all subjects (n = 14,114; p < 0.0001). In contrast, CRP level had a significantly inverse correlation with lymphocyte percentage (p < 0.0001). A proposed new reference range for total leukocyte count was estimated based on the data in the normal CRP level group (CRP < 0. 1 mg/dL; n = 4839). To rest on the essence of statistics that the range of [mean ± 2 standard deviations] contains approximately the middle 95% of observations in a sampled population, a new reference range for total leukocyte count was accordingly estimated to be 3.11-8.83 × 109/L. Conclusion: In view of the abundant evidence showing that a higher peripheral total leukocyte count is harmful to health, a down-correction of its upper reference range from the currently used 11.0 × 109/L to the proposed 8.83 × 109/L, based on a normal CRP level, should allow more abnormal health conditions to be identified and promote the usefulness of peripheral leukocyte analysis. ? 2007 Elsevier & Formosan Medical Association. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/480845 | ISSN: | 0929-6646 | DOI: | 10.1016/S0929-6646(08)60017-0 | SDG/關鍵字: | C reactive protein; adolescent; adult; aged; article; controlled study; female; human; leukocyte count; leukocyte differential count; lymphocyte count; major clinical study; male; monocyte; neutrophil count; protein blood level; reference value |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。