https://scholars.lib.ntu.edu.tw/handle/123456789/481050
Title: | Epithelial-myoepithelial carcinoma of the salivary gland harboring HRAS codon 61 mutations with lung metastasis | Authors: | MIN-SHU HSIEH JIN-SHING CHEN Lee Y.-H. Chou Y.-H. |
Issue Date: | 2015 | Publisher: | SAGE Publications Inc. | Journal Volume: | 24 | Journal Issue: | 3 | Start page/Pages: | 227-231 | Source: | International Journal of Surgical Pathology | Abstract: | Here, we report a case involving a 43-year-old man diagnosed with Burkitt lymphoma in 2007. At the same time, 2 small lung nodules were incidentally found; however, they presented no indication of growth throughout the follow-up period. However, a 1.5-cm nodule located in the right parotid gland in 2010 gradually increased in size to 2.8 cm by 2012. A parotidectomy revealed an epithelial-myoepithelial carcinoma, characterized by biphasic tubular structures and solid areas presenting myoepithelial overgrowth. Tumor necrosis and regional lymph node invasion were also observed. During clinical follow-up in 2013, a new 1.3-cm nodule was identified in the left lower lobe of the lung, which enlarged to 3 cm by 2014. Wedge resection of the left lung nodules revealed round nodes with well-defined borders. Histologically, these lung tumors predominantly comprised spindle-shaped myoepithelial cells with occasional tubular structures. Numerous cleft-like spaces lined by entrapped TTF-1-immunoreactive pneumocytes were observed inside the nodules. The lung nodules were characterized by a morphology similar to that of the parotid cancer. Epithelial-myoepithelial carcinoma with lung metastasis was confirmed by molecular testing, which revealed identical HRAS codon 61 (Q61K) mutations in the primary parotid tumor as well as in the lung metastases. ? The Author(s) 2015. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84964589359&doi=10.1177%2f1066896915622261&partnerID=40&md5=c9e0bf3bc17bf937786fd5d6339d7399 https://scholars.lib.ntu.edu.tw/handle/123456789/481050 |
ISSN: | 1066-8969 | DOI: | 10.1177/1066896915622261 | SDG/Keyword: | thyroid transcription factor 1; codon; HRAS protein, human; protein p21; adult; Article; Burkitt lymphoma; cancer diagnosis; case report; codon; computer assisted tomography; epithelial myoepithelial carcinoma of the salivary gland; follow up; gene mutation; hemicolectomy; histopathology; human; human tissue; immunoreactivity; incidental finding; intestine lymphoma; lung alveolus cell; lung lobe; lung metastasis; lung nodule; lymph node metastasis; male; molecular diagnosis; myoepithelium cell; oncogene H ras; parotid gland; parotid gland tumor; parotidectomy; priority journal; salivary gland carcinoma; tumor growth; tumor necrosis; wedge resection; Burkitt lymphoma; carcinoma; genetics; lung tumor; mutation; myoepithelioma; parotid gland tumor; pathology; reverse transcription polymerase chain reaction; second cancer; secondary; Adult; Burkitt Lymphoma; Carcinoma; Codon; Humans; Lung Neoplasms; Male; Mutation; Myoepithelioma; Neoplasms, Second Primary; Parotid Neoplasms; Proto-Oncogene Proteins p21(ras); Reverse Transcriptase Polymerase Chain Reaction |
Appears in Collections: | 醫學系 |
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