https://scholars.lib.ntu.edu.tw/handle/123456789/481424
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | KE-VIN CHANG | en_US |
dc.contributor.author | Hung C.-Y. | en_US |
dc.contributor.author | WEN-SHIANG CHEN | en_US |
dc.contributor.author | Lai M.-S. | en_US |
dc.contributor.author | KUO-LIONG CHIEN | en_US |
dc.contributor.author | DER-SHENG HAN | en_US |
dc.creator | Chang K.-V.;Hung C.-Y.;Wen-Shiang Chen;Lai M.-S.;Chien K.-L.;Han D.-S. | - |
dc.date.accessioned | 2020-03-30T13:03:34Z | - |
dc.date.available | 2020-03-30T13:03:34Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84896739765&doi=10.1371%2fjournal.pone.0081124&partnerID=40&md5=e26e08882d31652e9f88d36fe70f0778 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/481424 | - |
dc.description.abstract | Background: Various pharmacologic and non-pharmacologic approaches have been applied to reduce sublesional bone loss after spinal cord injury (SCI), and the results are inconsistent across the studies. The objective of this meta-analysis was to investigate whether the two most-studied interventions, bisphosphonate analogues and functional electrical stimulation (FES), could effectively decrease bone mineral density (BMD) attenuation and/or restore lost BMD in the SCI population. Methods: Randomized controlled trials, quasi-experimental studies, and prospective follow-up studies employing bisphosphonates or FES to treat post-SCI osteoporosis were identified in PubMed and Scopus. The primary outcome was the percentage of BMD change from baseline measured by dual-energy X-ray absorptiometry (DEXA) or computed tomography (CT). Data were extracted from four points: the 3rd, 6th, 12th, and 18th month after intervention. Results: A total of 19 studies were included in the analysis and involved 364 patients and 14 healthy individuals. Acute SCI participants treated with bisphosphonate therapy demonstrated a trend toward less bone loss than participants who received placebos or usual care. A significant difference in BMD decline was noted between both groups at the 3rd and 12th month post-medication. The subgroup analysis failed to show the superiority of intravenous bisphosphonate over oral administration. Regarding FES training, chronic SCI patients had 5.96% (95% CI, 2.08% to 9.84%), 7.21% (95%CI, 1.79% to 12.62%), and 9.56% (95% CI, 2.86% to 16.26%) increases in BMD at the 3rd, 6th, and 12th months post-treatment, respectively. The studies employing FES ?5 days per week were likely to have better effectiveness than studies using FES ?3 days per week. Conclusions: Our meta-analysis indicated bisphosphonate administration early following SCI effectively attenuated sublesional bone loss. FES intervention for chronic SCI patients could significantly increase sublesional BMD near the site of maximal mechanical loading. ? 2013 Chang et al. | - |
dc.relation.ispartof | PLoS ONE | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | alendronic acid; bisphosphonic acid derivative; calcium; etidronic acid; pamidronic acid; placebo; zoledronic acid; bisphosphonic acid derivative; bone density conservation agent; article; bone density; clinical effectiveness; computer assisted tomography; dizziness; drug dosage form comparison; dual energy X ray absorptiometry; fever; flu like syndrome; functional electrical stimulation; gastrointestinal symptom; headache; human; mechanical stress; meta analysis; multiple cycle treatment; myalgia; osteolysis; osteoporosis; rash; spinal cord injury; systematic review; treatment outcome; adverse effects; complication; drug effects; electrostimulation; osteoporosis; procedures; spinal cord injury; Bone Density; Bone Density Conservation Agents; Diphosphonates; Electric Stimulation; Humans; Osteoporosis; Spinal Cord Injuries; Treatment Outcome | - |
dc.title | Effectiveness of bisphosphonate analogues and functional electrical stimulation on attenuating post-injury osteoporosis in spinal cord injury patients- A Systematic Review and Meta-Analysis | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1371/journal.pone.0081124 | - |
dc.identifier.pmid | 24278386 | - |
dc.identifier.scopus | 2-s2.0-84896739765 | - |
dc.relation.pages | e81124 | - |
dc.relation.journalvolume | 8 | - |
dc.relation.journalissue | 11 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Physical Medicine and Rehabilitation | - |
crisitem.author.dept | Physical Medicine and Rehabilitation-NTUHBH | - |
crisitem.author.dept | Physical Medicine and Rehabilitation | - |
crisitem.author.dept | Physical Medicine and Rehabilitation-NTUH | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | Public Health | - |
crisitem.author.dept | Physical Medicine and Rehabilitation | - |
crisitem.author.dept | Physical Medicine and Rehabilitation-NTUHBH | - |
crisitem.author.orcid | 0000-0002-6686-806X | - |
crisitem.author.orcid | 0000-0003-1488-5164 | - |
crisitem.author.orcid | 0000-0003-4979-8351 | - |
crisitem.author.orcid | 0000-0001-7642-8060 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital Bei-Hu Branch | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital Bei-Hu Branch | - |
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