https://scholars.lib.ntu.edu.tw/handle/123456789/481583
標題: | Tag single nucleotide polymorphisms of alcohol-metabolizing enzymes modify the risk of upper aerodigestive tract cancers: HapMap database analysis | 作者: | Chung C.-S. YI-CHIA LEE JYH-MING LIOU CHENG-PING WANG JENG-YUH KO JANG-MING LEE MING-SHIANG WU HSIU-PO WANG |
公開日期: | 2014 | 出版社: | John Wiley and Sons Inc. | 卷: | 27 | 期: | 5 | 起(迄)頁: | 493-503 | 來源出版物: | Diseases of the Esophagus | 摘要: | Summary: Although alcohol is associated with higher upper aerodigestive tract (UADT) cancer risk, only a small fraction of alcoholics develop cancers. There is a lack of evidence proving the association of tag single nucleotide polymorphisms of alcohol-metabolizing enzymes with cancer risk. The aim of this study was to determine the association of these genetic polymorphisms with UADT cancer risk in a Chinese population. It was a hospital-based case-control candidate gene study. The databases of the International HapMap Project were searched for haplotype tag single nucleotide polymorphisms of the genes alcohol dehydrogenase (ADH)1B, ADH1C, and aldehyde dehydrogenase (ALDH)2. The genotyping was performed by the Sequenom MassARRAY system. Totally, 120 head and neck squamous cell carcinoma, 138 esophageal squamous cell carcinoma patients, and 276 age- and gender-matched subjects were enrolled between June 2008 and June 2010.Minor alleles of ADH1B (rs1229984) and ALDH2(rs671) were not only associated with the risk of UADT cancers (odds ratio [OR] [95% confidence interval, CI]: 3.53 [2.14-5.80] and 2.59 [1.79-3.75], respectively) but also potentiated the carcinogenic effects of alcohol (OR [95% CI]: 53.44 [25.21-113.29] and 70.08 [33.65-145.95], respectively). Similar effects were observed for head/neck and esophageal cancer subgroups. Multivariate logistic regression analysis identified four significant risk factors, including habitual use of cigarettes, alcohol, betel quid, and lower body mass index (P < 0.001). The haplotypes GAGC (OR 1.61, 95% CI 1.08-2.40, P = 0.018) and CCAATG (OR 1.69, 95% CI 1.24-2.30, P < 0.001) on chromosomes 4 and 12, respectively, were associated with higher cancer risk. These findings suggested that risk allele or haplotype carriers who consume alcohol and other carcinogens should be advised to undergo endoscopy screening. The information can be used to determine the degree of susceptibility of each subject and can be combined with other environmental factors, like carcinogen consumption, in the screening analysis. ? 2012, Wiley Periodicals, Inc. and the International Society for Diseases of the Esophagus. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84903888189&doi=10.1111%2fj.1442-2050.2012.01437.x&partnerID=40&md5=946725aa06dabcf5e9a2151ba0ed4a72 https://scholars.lib.ntu.edu.tw/handle/123456789/481583 |
ISSN: | 1120-8694 | DOI: | 10.1111/j.1442-2050.2012.01437.x | SDG/關鍵字: | alcohol; alcohol dehydrogenase; alcohol dehydrogenase 1B; alcohol dehydrogenase 1C; aldehyde dehydrogenase isoenzyme 2; carcinogen; DNA; unclassified drug; ADH1B protein, human; ADH1C protein, human; alcohol dehydrogenase; aldehyde dehydrogenase; ALDH2 protein, human; adult; aged; alcohol consumption; alcoholism; allele; article; body mass; cancer risk; Chinese; chromosome 12; chromosome 4; controlled study; digestive system cancer; DNA extraction; esophageal squamous cell carcinoma; female; gene frequency; genetic association; genetic polymorphism; genotype; genotype environment interaction; haplotype; haplotype map; head and neck squamous cell carcinoma; homozygote; hospital based case control study; human; major clinical study; male; priority journal; single nucleotide polymorphism; smoking; upper aerodigestive tract cancer; adverse effects; Areca; Carcinoma, Squamous Cell; case control study; drinking behavior; ethnic group; genetic predisposition; genetics; Head and Neck Neoplasms; middle aged; multivariate analysis; nucleic acid database; population genetics; risk factor; Taiwan; Alcohol Dehydrogenase; Alcohol Drinking; Aldehyde Dehydrogenase; Areca; Body Mass Index; Carcinoma, Squamous Cell; Case-Control Studies; Databases, Nucleic Acid; Ethnic Groups; Female; Genetic Predisposition to Disease; Genetics, Population; Haplotypes; Head and Neck Neoplasms; Humans; Male; Middle Aged; Multivariate Analysis; Polymorphism, Single Nucleotide; Risk Factors; Smoking; Taiwan |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。