https://scholars.lib.ntu.edu.tw/handle/123456789/483561
Title: | Is serum hypovitaminosis D associated with chronic widespread pain including fibromyalgia? A meta-analysis of observational studies | Authors: | MING-YEN HSIAO Hung C.-Y. KE-VIN CHANG DER-SHENG HAN TYNG-GUEY WANG |
Issue Date: | 2015 | Publisher: | American Society of Interventional Pain Physicians | Journal Volume: | 18 | Journal Issue: | 5 | Start page/Pages: | E877-E887 | Source: | Pain Physician | Abstract: | Background: Chronic widespread pain (CWP) is a global musculoskeletal disorder leading todisability and a reduced quality of life. Low levels of serum vitamin D has long been proposedto be associated with CWP, but previous research remains inconclusive.Objectives: To determine whether hypovitaminosis D was independently associated withCWP.Study Design: Meta-analysis of observational study.Methods: Electronic databases were searched for studies published up to November 2014comparing the prevalence of hypovitaminosis D and serum vitamin D levels between participantswith and without CWP. The crude and adjusted odds ratios (ORs) of hypovitaminosis D withCWP were calculated. Subgroup analysis according to gender, threshold of hypovitaminosis,and definition of patients was performed, as well as meta-regression to test the linearrelationship between crude ORs and the latitude of study locations.Results: Twelve studies were included, comprising 1,854 patients with CWP. The patientgroup showed a significantly higher risk of hypovitaminosis D than the control group (crudeOR, 1.63; 95% CI, 1.20 – 2.23). The association was slightly attenuated after adjustingconfounders, with a pooled adjusted OR of 1.41 (95% CI, 1.00 – 2.00). There was an increasein ORs of hypovitaminosis D using a lower diagnostic value of serum vitamin D (8 and 10ng/mL). The subgroup analysis according to gender and definition of CWP did not revealsignificant between-group differences. The meta-regression showed no linear relationshipbetween latitude and the crude ORs.Conclusions: There was a positive crude association between hypovitaminosis D and CWP,and the association was likely to remain after adjusting confounding factors. Use of a cut-offvalue of hypovitaminosis D (8 – 10 ng/mL) could better define the population with and withoutCWP. Further prospective follow-up studies are warranted to clarify the causal relationshipbetween hypovitaminosis D and CWP. ? 2015, American Society of Interventional Pain Physicians. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84942090923&partnerID=40&md5=c95c31d920d3eb557830823a30d95e1c https://scholars.lib.ntu.edu.tw/handle/123456789/483561 |
ISSN: | 1533-3159 | SDG/Keyword: | vitamin D; age; Article; chronic pain; data processing; disease association; fibromyalgia; gender; human; meta analysis; quality of life; vitamin blood level; vitamin D deficiency; blood; chronic pain; complication; fibromyalgia; observational study; prevalence; vitamin D deficiency; Chronic Pain; Fibromyalgia; Humans; Observational Studies as Topic; Prevalence; Vitamin D Deficiency |
Appears in Collections: | 醫學系 |
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