https://scholars.lib.ntu.edu.tw/handle/123456789/484094
標題: | Hospital volume of percutaneous radiofrequency ablation is closely associated with treatment outcomes for patients with hepatocellular carcinoma | 作者: | LI-CHUN LU YU-YUN SHAO Kuo R.N.C. ZHONG-ZHE LIN Yeh Y.-C. Shau W.-Y. CHIH-HUNG HSU ANN-LII CHENG Lai M.-S. |
公開日期: | 2013 | 卷: | 119 | 期: | 6 | 起(迄)頁: | 1210-1216 | 來源出版物: | Cancer | 摘要: | Background: Hospital volume for several major operations is associated with treatment outcomes. In this study, the authors explored the influence of hospital radiofrequency ablation (RFA) volume on the prognosis of patients who received RFA for hepatocellular carcinoma (HCC). METHODS: The authors searched for all patients who were diagnosed with stage I or stage II HCC from 2004 to 2006 and who received RFA as first-line therapy in a population-based cohort. Overall survival (OS) and liver cancer-specific survival (CSS) were compared according to hospital volume. A Cox proportional hazards model was used for multivariate analysis. RESULTS: In total, 661 patients received first-line RFA for stage I and II HCC in 28 hospitals. Among these, there were 480 patients (72.6%) in the high-volume group (those who received RFA at hospitals that treated >10 first-line patients per year), and there were 181 patients (27.4%) in the low-volume group (those who received RFA at hospitals that treated ?10 first-line patients per year). The sex, age, stage, tumor size, and year of diagnosis for patients in the 2 groups did not differ significantly. Patients in the high-volume group demonstrated significantly longer OS and CSS than those in the low-volume group (5-year OS rate, 58.7% vs 47.2%; P =.001; 5-year CSS rate, 67.1% vs 57.1%; P =.009). After adjusting for covariates, high-volume hospitals remained an independent predictor of longer OS (hazard ratio, 0.57; P <.001) and CSS (hazard ratio, 0.57; P =.003). CONCLUSIONS: Patients who received first-line RFA for HCC in high-volume hospitals demonstrated better survival outcomes. Cancer 2013. ? 2012 American Cancer Society. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84874690099&doi=10.1002%2fcncr.27800&partnerID=40&md5=8b491713aa0ea8dec1fff0d54211c50f https://scholars.lib.ntu.edu.tw/handle/123456789/484094 |
ISSN: | 0008-543X | DOI: | 10.1002/cncr.27800 | SDG/關鍵字: | adult; age distribution; aged; article; cancer prognosis; cancer specific survival; cancer staging; cohort analysis; controlled study; female; hospital patient; human; liver cell carcinoma; major clinical study; male; overall survival; population research; priority journal; radiofrequency ablation; sex difference; survival rate; treatment outcome; tumor volume; Carcinoma, Hepatocellular; Catheter Ablation; Female; Humans; Liver Neoplasms; Male; Surgery Department, Hospital; Survival Rate; Treatment Outcome |
顯示於: | 腫瘤醫學研究所 |
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