https://scholars.lib.ntu.edu.tw/handle/123456789/484118
標題: | Fatal thrombocytopenia after oxaliplatin-based chemotherapy | 作者: | YU-YUN SHAO RUEY-LONG HONG |
公開日期: | 2008 | 卷: | 28 | 期: | 5 B | 起(迄)頁: | 3115-3117 | 來源出版物: | Anticancer Research | 摘要: | Oxaliplatin-related thrombocytopenia is considered rare and mostly self-limited. We present the first reported fatal case due to this complication. A 64-year-old patient with metastatic colon cancer was admitted for his 24th course of chemotherapy with oxaliplatin and 24-hour infusion of fluorouracil and leucovorin. Consciousness changed on the next evening and deteriorated to deep coma within hours. Computed tomography revealed large intracranial hemorrhage with brain herniation. Hemogram showed severe thrombocytopenia, which was considered to be associated with oxaliplatin. The patient died six days later. The incidence of oxaliplatin-related thrombocytopenia may have been underestimated and its severity long neglected. Other hypersensitivity reactions may precede its onset. Early hemogram examination during hypersensitivity reaction to oxaliplatin may provide early diagnosis and the prevention of the possible fatal consequences. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-55749096402&partnerID=40&md5=348c50d6e656abcbc818d5b1577daa55 https://scholars.lib.ntu.edu.tw/handle/123456789/484118 |
ISSN: | 0250-7005 | SDG/關鍵字: | antihistaminic agent; fluorouracil; folinic acid; oxaliplatin; steroid; adult; article; brain hernia; case report; chill; colon cancer; computer assisted tomography; human; hypersensitivity reaction; incidence; male; priority journal; rash; thrombocytopenia; tremor; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fatal Outcome; Fluorouracil; Humans; Intracranial Hemorrhages; Male; Middle Aged; Organoplatinum Compounds; Thrombocytopenia |
顯示於: | 腫瘤醫學研究所 |
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