https://scholars.lib.ntu.edu.tw/handle/123456789/485679
標題: | Prone breast forward intensity-modulated radiotherapy for asian women with early left breast cancer: Factors for cardiac sparing and clinical outcomes | 作者: | JENNY LING-YU CHEN CHIA-HSIEN CHENG SUNG-HSIN KUO Chan H.-M. YU-SEN HUANG YU-HSUAN CHEN |
公開日期: | 2013 | 卷: | 54 | 期: | 5 | 起(迄)頁: | 899-908 | 來源出版物: | Journal of Radiation Research | 摘要: | Since December 2009, after breast-conserving surgery for Stage 0-I cancer of the left breast, 21 women with relatively pendulous breasts underwent computed tomography prone and supine simulations. The adjuvant radiotherapy was 50 Gy in 25 fractions to the left breast alone. Four plans-conventional wedged tangents and forward intensity-modulated radiotherapy (fIMRT) in supine and prone positions-were generated. fIMRT generated better homogeneity in both positions. Prone position centralized the breast tissue by gravity and also shortened the breast width which led to better conformity in both planning techniques. Prone fIMRT significantly reduced doses to left lung, Level I and Level II axilla. The mean cardiac doses did not differ between positions. Among the four plans, prone fIMRT produced the best target dosimetry and normal organ sparing. In subgroup analysis, patients with absolute breast depth > 7 cm in the prone position or breast depth difference > 3 cm between positions had significant cardiac sparing with prone fIMRT. Sixteen patients with significant cardiac sparing in prone position were treated using prone fIMRT and the others using supine fIMRT. All patients received a supine electron tumor bed boost of 10 Gy in 5 fractions. No patients developed Grade 2 or worse acute or late toxicities. There was no difference in the number of segments or beams, monitor units, treatment time, or positioning reproducibility between prone and supine positions. At a median follow-up time of 26.8 months, no locoregional or distant recurrence or death was noted. ? The Author 2013. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84888211122&doi=10.1093%2fjrr%2frrt019&partnerID=40&md5=5023e9a4869bf5220853eccda89ccb26 https://scholars.lib.ntu.edu.tw/handle/123456789/485679 |
ISSN: | 0449-3060 | DOI: | 10.1093/jrr/rrt019 | SDG/關鍵字: | Computerized tomography; Diseases; Radiotherapy; Asian woman; Breast Cancer; Breast radiotherapy; Breast tangent; Breast-conserving surgery; Clinical outcome; Intensity-modulated radiotherapy; Prone breast radiotherapy; Prone position; Supine position; Heart; adjuvant therapy; adult; article; Asian women; body posture; breast cancer; breast tangents; breast tumor; clinical trial; computer assisted radiotherapy; conservative treatment; female; heart injury; human; intensity modulated radiation therapy; methodology; middle aged; patient positioning; prone breast radiotherapy; radiation injury; segmental mastectomy; treatment outcome; young adult; Asian women; breast cancer; breast tangents; intensity-modulated radiotherapy; prone breast radiotherapy; Adult; Breast Neoplasms; Female; Heart Injuries; Humans; Mastectomy, Segmental; Middle Aged; Organ Sparing Treatments; Patient Positioning; Prone Position; Radiation Injuries; Radiotherapy, Adjuvant; Radiotherapy, Conformal; Treatment Outcome; Young Adult |
顯示於: | 腫瘤醫學研究所 |
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