https://scholars.lib.ntu.edu.tw/handle/123456789/487361
標題: | Long-term hepatic consequences of chemotherapy-related HBV reactivation in lymphoma patients | 作者: | Su W.-P. Wen C.-C. Hsiung C.A. Su I.-J. ANN-LII CHENG Chang M.-C. Tsao C.-J. Kao W.-Y. Uen W.-C. CHIH-HUNG HSU YEN-SHEN LU HWEI-FANG TIEN Chao T.-Y. Chen L.-T. Whang-Peng J. PEI-JER CHEN |
公開日期: | 2005 | 出版社: | WJG Press | 卷: | 11 | 期: | 34 | 起(迄)頁: | 5283-5288 | 來源出版物: | World Journal of Gastroenterology | 摘要: | Aim: To investigate the long-term consequences of chemotherapy-related HBV reactivation in patients with lymphoma. Methods: This study was based on the database of published prospective study evaluating HBV reactivation in HBV lymphoma patients during chemotherapy. Deteriorated liver reserve (DLR) was defined as development of either one of the following conditions during follow-up: (1) newly onset parenchyma liver disease, splenomegaly or ascites without evidence of lymphoma involvement; (2) decrease of the ratio (albumin/globulin ratio) to less than 0.8 or increase of the ratio of INR of prothrombin time to larger than 1.2 without evidence of malnutrition or infection. Liver cirrhosis was diagnosed by imaging studies. Results: A total of 49 patients were included. The median follow-up was 6.2 years (range, 3.9-8.1 years). There were 31 patients with and 18 patients without HBV reactivation. Although there was no difference of overall survival (OS) and chemotherapy response rate between the two groups, DLR developed more frequently in patients with HBV reactivation (48.4% vs 16.7%; P = 0.0342). Among the HBV reactivators, HBV genotype C was associated with a higher risk of developing DLR (P = 0.0768) and liver cirrhosis (P = 0.003). Four of five patients with sustained high titer of HBV DNA and two of three patients with multiple HBV reactivation developed DLR. Further, patients with a sustained high titer of HBV DNA had the shortest OS among the HBV reactivators (P = 0.0000). No patients in the non-HBV reactivation group developed hepatic failure or liver cirrhosis. Conclusion: Chemotherapy-related HBV reactivation is associated with the long-term effect of deterioration of hepatic function. ? 2005 The WJG Press and Elsevier Inc. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84983718388&doi=10.3748%2fwjg.v11.i34.5283&partnerID=40&md5=65854d1c4a4b04dd084ac1d50db345df https://scholars.lib.ntu.edu.tw/handle/123456789/487361 |
ISSN: | 1007-9327 | DOI: | 10.3748/wjg.v11.i34.5283 | SDG/關鍵字: | albumin; cytotoxic agent; globulin; prothrombin; virus DNA; adult; albumin blood level; article; ascites; cancer combination chemotherapy; cancer survival; clinical article; controlled study; data base; diagnostic imaging; drug response; female; follow up; genotype; Hepatitis B virus; human; infection; international normalized ratio; liver cell damage; liver cirrhosis; liver dysfunction; liver failure; liver function; lymphoma; male; malnutrition; nonhuman; publication; risk factor; splenomegaly; survival rate; virus reactivation; virus titration |
顯示於: | 腫瘤醫學研究所 |
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