https://scholars.lib.ntu.edu.tw/handle/123456789/490892
Title: | Hispidulin attenuates the social withdrawal in isolated disrupted-in-schizophrenia-1 mutant and chronic phencyclidine-treated mice | Authors: | Mouri, Akihiro Lee, Hsin-Jung Mamiya, Takayoshi Aoyama, Yuki Matsumoto, Yurie Kubota, Hisayoshi Huang, Wei-Jan LIH-CHU CHIOU Nabeshima, Toshitaka |
Issue Date: | 4-Mar-2020 | Publisher: | WILEY | Source: | British journal of pharmacology | Abstract: | Hispidulin is a flavonoid isolated from Clerodendrum inerme that was found to inhibit intractable motor tics. Previously, we found that hispidulin attenuates hyperlocomotion and the disrupted prepulse inhibition induced by methamphetamine and N-methyl-d-aspartate (NMDA) receptor antagonists, two phenotypes of schizophrenia resembling positive symptoms. Hispidulin can inhibit COMT, a dopamine-metabolizing enzyme in the prefrontal cortex (PFC) that is important for social interaction. Here, we investigated whether hispidulin would affect social withdrawal, one of the negative symptoms of schizophrenia. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/490892 | ISSN: | 0007-1188 | DOI: | 10.1111/bph.15043 |
Appears in Collections: | 腦與心智科學研究所 |
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