https://scholars.lib.ntu.edu.tw/handle/123456789/494234
標題: | Plasma calcitonin gene-related peptide in diagnosing and predicting paediatric migraine | 作者: | PI-CHUAN FAN PING-HUNG KUO SHU-HUI CHANG WANG-TSO LEE RUEY-MEEI WU LIH-CHU CHIOU |
關鍵字: | CGRP; migraine; paediatric; disability | 公開日期: | 八月-2009 | 出版社: | SAGE PUBLICATIONS LTD | 卷: | 29 | 期: | 8 | 起(迄)頁: | 883 | 來源出版物: | Cephalalgia : an international journal of headache | 摘要: | To investigate the role of plasma calcitonin gene-related peptide (CGRP) in paediatric migraine, we prospectively collected 134 blood samples during or between attacks from 66 migraine, 33 non-migraine headache (non-migraine) and 22 non-headache patients, aged 4-18 years. Plasma CGRP concentrations were measured by enzyme-linked immunosorbent assay and disability by Pediatric MIgraine Disability ASsessment (PedMIDAS) questionnaire. Migraineurs had higher plasma CGRP levels than non-migraine patients (P = 0.007). The attack level was higher than the non-attack level in migraine (P = 0.036), but not in non-migraine, patients. This was also revealed in paired comparison (n = 9, P = 0.015 vs. n = 4, P = 0.47). Using a threshold of 55.1 pg/ml, the sensitivity of the attack level in predicting migraine was 0.81, and specificity 0.75. The PedMIDAS score tended to be higher in the high CGRP (> 200 pg/ml, n = 7) group than in the low (< 200 pg/ml, n = 33) group (26.07 vs. 19.32, P = 0.16) using Mann-Whitney test. Plasma CGRP is useful for diagnosis in paediatric migraine. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/494234 | ISSN: | 0333-1024 | DOI: | 10.1111/j.1468-2982.2008.01816.x |
顯示於: | 流行病學與預防醫學研究所 |
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