https://scholars.lib.ntu.edu.tw/handle/123456789/494494
Title: | Genetic polymorphisms of PCSK2 are associated with glucose homeostasis and progression to type 2 diabetes in a Chinese population | Authors: | TIEN-JYUN CHANG Chiu Y.-F. Sheu W.H.-H. Shih K.-C. Hwu C.-M. Quertermous T. Jou Y.-S. Kuo S.-S. YI-CHENG CHANG LEE-MING CHUANG |
Issue Date: | 2015 | Publisher: | Nature Publishing Group | Journal Volume: | 5 | Start page/Pages: | 14380 | Source: | Scientific Reports | Abstract: | Proprotein convertase subtilisin/kexin type 2 (PCSK2) is a prohormone processing enzyme involved in insulin and glucagon biosynthesis. We previously found the genetic polymorphism of PCSK2 on chromosome 20 was responsible for the linkage peak of several glucose homeostasis parameters. The aim of this study is to investigate the association between genetic variants of PCSK2 and glucose homeostasis parameters and incident diabetes. Total 1142 Chinese participants were recruited from the Stanford Asia-Pacific Program for Hypertension and Insulin Resistance (SAPPHIRe) family study, and 759 participants were followed up for 5 years. Ten SNPs of the PCSK2 gene were genotyped. Variants of rs6044695 and rs2284912 were associated with fasting plasma glucose, and variants of rs2269023 were associated with fasting plasma glucose and 1-hour plasma glucose during OGTT. Haplotypes of rs4814605/rs1078199 were associated with fasting plasma insulin levels and HOMA-IR. Haplotypes of rs890609/rs2269023 were also associated with fasting plasma glucose, fasting insulin and HOMA-IR. In the longitudinal study, we found individuals carrying TA/AA genotypes of rs6044695 or TC/CC genotypes of rs2284912 had lower incidence of diabetes during the 5-year follow-up. Our results indicated that PCSK2 gene polymorphisms are associated with pleiotropic effects on various traits of glucose homeostasis and incident diabetes. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84948447166&doi=10.1038%2fsrep14380&partnerID=40&md5=fd88e2fb156facf3d148586bb158dee8 https://scholars.lib.ntu.edu.tw/handle/123456789/494494 |
ISSN: | 2045-2322 | DOI: | 10.1038/srep14380 | SDG/Keyword: | glucose blood level; PCSK2 protein, human; proprotein convertase 2; Asian continental ancestry group; China; Diabetes Mellitus, Type 2; disease course; female; follow up; gene linkage disequilibrium; genetic predisposition; genetics; genome-wide association study; glucose blood level; haplotype; homeostasis; human; incidence; male; metabolism; middle aged; single nucleotide polymorphism; Asian Continental Ancestry Group; Blood Glucose; China; Diabetes Mellitus, Type 2; Disease Progression; Female; Follow-Up Studies; Genetic Predisposition to Disease; Genome-Wide Association Study; Haplotypes; Homeostasis; Humans; Incidence; Linkage Disequilibrium; Male; Middle Aged; Polymorphism, Single Nucleotide; Proprotein Convertase 2 |
Appears in Collections: | 醫學系 |
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