https://scholars.lib.ntu.edu.tw/handle/123456789/495443
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | PEI-LUNG CHEN | en_US |
dc.contributor.author | Fann C.S.-J. | en_US |
dc.contributor.author | Chang C.-C. | en_US |
dc.contributor.author | Wu I.-L. | en_US |
dc.contributor.author | WEI-YIH CHIU | en_US |
dc.contributor.author | Lin C.-Y. | en_US |
dc.contributor.author | WEI-SHIUNG YANG | en_US |
dc.contributor.author | TIEN-CHUN CHANG | en_US |
dc.creator | Chang T.-C.;Yang W.-S.;Lin C.-Y.;WEI-YIH CHIU;Wu I.-L.;Chang C.-C.;Fann C.S.-J.;Chen P.-L. | - |
dc.date.accessioned | 2020-06-01T03:27:15Z | - |
dc.date.available | 2020-06-01T03:27:15Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0300-0664 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-34247860724&doi=10.1111%2fj.1365-2265.2007.02787.x&partnerID=40&md5=8842d9c00928343e8d4124c28d665af7 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/495443 | - |
dc.description.abstract | Objective: To investigate whether markers in the candidate chromosome regions, including the human leucocyte antigen (HLA) region, are linked to Graves' disease (GD). Design: A familial linkage study with a candidate region approach. Patients: A total of 536 individuals in 122 multiplex Chinese-Han families with a GD proband and at least one other affected sibling, resulting in 270 affected sib-pairs. Subjects with a family history of noniatrogenic hypothyroidism or Hashimoto's thyroiditis were excluded. Measurements: We genotyped eight short tandem repeat polymorphism (STRP) markers in a 13.7 cM region covering the HLA region on chromosome 6p21 and 26 STRPs in four other candidate regions previously reported in the literature. Results: Multipoint nonparametric linkage (NPL) analysis showed significant linkage to the HLA region [the marker UniSTS:239159, nonparametric log of odds (LOD) score 3.44, P = 0.00003; NPL Z-score 4.1, P = 0.00002] from 270 affected sib-pairs. The 1-LOD support interval comprised the whole HLA region (ca. 4 Mb). By contrast, the maximal NPL Z-scores of the markers of the other candidate regions (2q33, 5q31, 7q22 and 14q31) previously reported were all less than 1.0. Conclusions: Our results provide strong support for linkage of GD to the HLA region. Further dissection of this region to identify the candidate gene for GD is warranted in our population. ? 2007 The Authors. | - |
dc.relation.ispartof | Clinical Endocrinology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | biological marker; article; Chinese; chromosome 14q; chromosome 2q; chromosome 5q; chromosome 6p; chromosome 7q; controlled study; familial disease; family history; female; genetic association; genetic linkage; genetic polymorphism; genotype; Graves disease; Hashimoto disease; HLA system; human; hypothyroidism; iatrogenic disease; major clinical study; male; nonparametric test; priority journal; scoring system; short tandem repeat; sibling; Taiwan; Asian Continental Ancestry Group; Chromosome Mapping; Female; Genetic Markers; Genetic Predisposition to Disease; Graves Disease; Humans; Linkage (Genetics); Lod Score; Major Histocompatibility Complex; Male; Microsatellite Repeats; Taiwan | - |
dc.title | Linkage of Graves' disease to the human leucocyte antigen region in the Chinese-Han population in Taiwan | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1111/j.1365-2265.2007.02787.x | - |
dc.identifier.pmid | 17492952 | - |
dc.identifier.scopus | 2-s2.0-34247860724 | - |
dc.relation.pages | 646-651 | - |
dc.relation.journalvolume | 66 | - |
dc.relation.journalissue | 5 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Medical Genomics and Proteomics | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Medical Genetics-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUHYL | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-5640-3074 | - |
crisitem.author.orcid | 0000-0003-3124-7121 | - |
crisitem.author.orcid | 0000-0001-5087-373X | - |
crisitem.author.orcid | 0000-0003-3385-2026 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital Yun-Lin Branch | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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