https://scholars.lib.ntu.edu.tw/handle/123456789/495528
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | YI-CHENG CHANG | en_US |
dc.contributor.author | Chiu Y.-F. | en_US |
dc.contributor.author | Lee I.-T. | en_US |
dc.contributor.author | Ho L.-T. | en_US |
dc.contributor.author | Hung Y.-J. | en_US |
dc.contributor.author | Hsiung C.A. | en_US |
dc.contributor.author | Quertermous T. | en_US |
dc.contributor.author | Donlon T. | en_US |
dc.contributor.author | Lee W.-J. | en_US |
dc.contributor.author | PO-CHU LEE | en_US |
dc.contributor.author | Chen C.-H. | en_US |
dc.contributor.author | Mochly-Rosen D. | en_US |
dc.contributor.author | LEE-MING CHUANG | en_US |
dc.creator | LEE-MING CHUANG;Mochly-Rosen D.;Chen C.-H.;Lee P.-C.;Lee W.-J.;Donlon T.;Quertermous T.;Hsiung C.A.;Hung Y.-J.;Ho L.-T.;Lee I.-T.;Chiu Y.-F.;Chang Y.-C. | - |
dc.date.accessioned | 2020-06-01T04:30:28Z | - |
dc.date.available | 2020-06-01T04:30:28Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1471-2261 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84864223345&doi=10.1186%2f1471-2261-12-58&partnerID=40&md5=33609ae85a89579e6606c9144de5b42c | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/495528 | - |
dc.description.abstract | Background: Genetic variants near/within the ALDH2 gene encoding the mitochondrial aldehyde dehydrogenase 2 have been associated with blood pressure and hypertension in several case-control association studies in East Asian populations.Methods: Three common tag single nucleotide polymorphisms (tagSNP) in the ALDH2 gene were genotyped in 1,134 subjects of Chinese origin from the Stanford Asia-Pacific Program for Hypertension and Insulin Resistance (SAPPHIRe) family cohort. We examined whether the ALDH2 SNP genotypes predicted the development of hypertension in the prospective SAPPHIRe cohort.Results: Over an average follow-up period of 5.7 years, carriers homozygous for the rs2238152 T allele in the ALDH2 gene were more likely to progress to hypertension than were non-carriers (hazard ratio [HR], 2.88, 95% confidence interval [CI], 1.06-7.84, P = 0.03), corresponding to a population attributable risk of ~7.1%. The risk associated with the rs2238152 T allele were strongest in heavy/moderate alcohol drinkers and was reduced in non-drinkers, indicating an interaction between ALDH2 genetic variants and alcohol intake on the risk of hypertension (P for interaction = 0.04). The risk allele was associated with significantly lower ALDH2 gene expression levels in human adipose tissue.Conclusion: ALDH2 genetic variants were associated with progression to hypertension in a prospective Chinese cohort. The association was modified by alcohol consumption. ? 2012 Chang et al.; licensee BioMed Central Ltd. | en_US |
dc.relation.ispartof | BMC Cardiovascular Disorders | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | messenger RNA; adipose tissue; adult; alcohol consumption; ALDH2 gene; allele; article; Chinese; cohort analysis; diastolic blood pressure; disease course; female; follow up; gene; gene expression; gene frequency; genotype; genotype environment interaction; homozygosity; human; human tissue; hypertension; major clinical study; male; morbid obesity; pathogenesis; priority journal; risk assessment; single nucleotide polymorphism; systolic blood pressure; Adipose Tissue; Adult; Alcohol Drinking; Aldehyde Dehydrogenase; Asian Continental Ancestry Group; Blood Pressure; China; Disease Progression; Female; Gene Frequency; Gene-Environment Interaction; Genetic Predisposition to Disease; Homozygote; Humans; Hypertension; Male; Middle Aged; Phenotype; Polymorphism, Single Nucleotide; Prospective Studies; Risk Assessment; Risk Factors; Taiwan; Time Factors; Young Adult | - |
dc.title | Common ALDH2 genetic variants predict development of hypertension in the SAPPHIRe prospective cohort: Gene-environmental interaction with alcohol consumption | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1186/1471-2261-12-58 | - |
dc.identifier.pmid | 22839215 | - |
dc.identifier.scopus | 2-s2.0-84864223345 | - |
dc.relation.pages | 58 | en_US |
dc.relation.journalvolume | 12 | en_US |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Medical Genomics and Proteomics | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-8077-5011 | - |
crisitem.author.orcid | 0000-0001-5053-1895 | - |
crisitem.author.orcid | 0000-0003-0978-2662 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
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