https://scholars.lib.ntu.edu.tw/handle/123456789/495611
標題: | Relationship between fasting plasma glucose and incidence of diabetes in children and adolescents | 作者: | Yang C.-Y. HUNG-YUAN LI Sung F.-C. Tan E.C.-H. Wei J.-N. LEE-MING CHUANG |
公開日期: | 2019 | 出版社: | Blackwell Publishing Ltd | 卷: | 36 | 期: | 5 | 起(迄)頁: | 633-643 | 來源出版物: | Diabetic Medicine | 摘要: | Aim: To investigate the appropriate fasting plasma glucose threshold by which to define prediabetes in children and adolescents, based on its ability to predict incident paediatric diabetes. Methods: In a nationwide survey of diabetes and renal disease conducted between 1992 and 2000 in all school-aged children in Taiwan, those with abnormal results in repeated urine tests received further physical examination and blood tests. Students who had blood tests for at least two time points were selected for the present study (N = 12 119). The incidence of paediatric diabetes, adjusted hazard ratio and predictive power of fasting plasma glucose were analysed. Results: The incidence of paediatric diabetes increased with increasing fasting plasma glucose levels. Groups with fasting plasma glucose >5.6 mmol/l had a higher adjusted hazard ratio. The adjusted hazard ratio of incident diabetes for participants with higher fasting plasma glucose rose continuously when using a higher threshold for fasting plasma glucose. The area under the receiver-operating characteristic curve for fasting plasma glucose was 0.628 for predicting paediatric diabetes. The association between fasting plasma glucose and incident paediatric diabetes and the area under the receiver-operating characteristic curve were similar in boys and girls and were higher in the age group 12–18 years. According to receiver-operating characteristic curve analysis, the optimal thresholds, sensitivity and specificity were 4.75 mmol/l, 65% and 51%, respectively, for those aged 6–11 years and 5.19 mmol/l, 60% and 73%, respectively, for those aged 12–18 years. Conclusion: Fasting plasma glucose is associated with the incidence of paediatric diabetes. The results of the present study can be used as reference data to suggest a cut-off value to define paediatric prediabetes. ? 2019 Diabetes UK |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85061987993&doi=10.1111%2fdme.13925&partnerID=40&md5=86dff45ab9f964fb86dd12fada1a89e4 https://scholars.lib.ntu.edu.tw/handle/123456789/495611 |
ISSN: | 0742-3071 | DOI: | 10.1111/dme.13925 | SDG/關鍵字: | glucose; adolescent; adolescent disease; adult; Article; blood examination; blood sampling; child; childhood disease; diabetes mellitus; family history; fasting; follow up; glucose blood level; health survey; human; impaired glucose tolerance; incidence; kidney disease; major clinical study; physical examination; practice guideline; urinalysis; urine sampling; blood; diet restriction; female; glucose blood level; impaired glucose tolerance; incidence; male; non insulin dependent diabetes mellitus; risk factor; sensitivity and specificity; Taiwan; Adolescent; Blood Glucose; Child; Diabetes Mellitus, Type 2; Fasting; Female; Follow-Up Studies; Humans; Incidence; Male; Prediabetic State; Risk Factors; Sensitivity and Specificity; Taiwan |
顯示於: | 醫學系 |
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