https://scholars.lib.ntu.edu.tw/handle/123456789/495668
Title: | Adiponectin mRNA levels in the abdominal adipose depots of nondiabetic women | Authors: | WEI-SHIUNG YANG Chen M.-H. Lee W.-J. Lee K.-C. Chao C.-L. KUO-CHIN HUANG CHI-LING CHEN TONG-YUAN TAI LEE-MING CHUANG |
Issue Date: | 2003 | Journal Volume: | 27 | Journal Issue: | 8 | Start page/Pages: | 896-900 | Source: | International Journal of Obesity | Abstract: | BACKGROUND: The human adiponectin gene has been implicated in the pathophysiology of obesity, type II diabetes mellitus, dyslipidemia and atherosclerosis. Investigation of the physiological functions of the adiponectin gene in humans was mainly conducted at the levels of plasma proteins or DNA polymorphisms. The depot-specific adiponectin mRNA levels also could be relevant to these physiological functions. OBJECTIVES: The relation between the adipose depot-specific adiponectin mRNA expression levels and various metabolic factors, including BMI, fasting plasma glucose, insulin, triglycerides (TGs) and HDL-cholesterol and insulin resistance index by HOMA, was investigated among 66 nondiabetic women using quantitative real-time PCR. RESULTS: The subcutaneous relative adiponectin mRNA levels (SRAmR) correlated significantly with the omental relative adiponectin mRNA levels (ORAmR) (γ=0.468, P=0.0001). The SRAmR correlated inversely with the fasting plasma glucose with a borderline significance (γ=-0.35, P=0.058). On the other hand, the ORAmR correlated negatively with serum TG levels with the adjustment for age (γ=-0.33, P=0.007) or age plus BMI (γ=-0.27, P=0.027). CONCLUSION: These results indicate that the adiponectin mRNA levels in different adipose depots were at least related to certain phenotypes of metabolic syndrome. The expression levels of adiponectin in the omental adipose depots are related to TG metabolism. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0041665074&doi=10.1038%2fsj.ijo.0802367&partnerID=40&md5=9109aad52e450b8a7a79853de51699fe https://scholars.lib.ntu.edu.tw/handle/123456789/495668 |
ISSN: | 0307-0565 | DOI: | 10.1038/sj.ijo.0802367 | SDG/Keyword: | adiponectin; glucose; high density lipoprotein cholesterol; insulin; messenger RNA; triacylglycerol; abdominal wall; adipose tissue; adult; article; DNA polymorphism; dyslipidemia; female; glucose blood level; human; human tissue; insulin resistance; insulin sensitivity; major clinical study; metabolic disorder; non insulin dependent diabetes mellitus; pathophysiology; priority journal; reverse transcription polymerase chain reaction; Abdomen; Adiponectin; Adipose Tissue; Adult; Aging; Blood Glucose; Body Mass Index; Cholesterol, HDL; Humans; Insulin; Insulin Resistance; Intercellular Signaling Peptides and Proteins; Middle Aged; Polymerase Chain Reaction; Proteins; RNA, Messenger |
Appears in Collections: | 醫學系 |
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