https://scholars.lib.ntu.edu.tw/handle/123456789/495703
標題: | Comparison of the Current Diagnostic Criterion of HbA1c with Fasting and 2-Hour Plasma Glucose Concentration | 作者: | Karnchanasorn R. Huang J. Ou H.-Y. Feng W. LEE-MING CHUANG Chiu K.C. Samoa R. |
公開日期: | 2016 | 出版社: | Hindawi Limited | 卷: | 2016 | 起(迄)頁: | 6195494 | 來源出版物: | Journal of Diabetes Research | 摘要: | To determine the effectiveness of hemoglobin A1c (HbA1c) ? 6.5% in diagnosing diabetes compared to fasting plasma glucose (FPG) ? 126 mg/dL and 2-hour plasma glucose (2hPG) ? 200 mg/dL in a previously undiagnosed diabetic cohort, we included 5,764 adult subjects without established diabetes for whom HbA1c, FPG, 2hPG, and BMI measurements were collected. Compared to the FPG criterion, the sensitivity of HbA1c ? 6.5% was only 43.3% (106 subjects). Compared to the 2hPG criterion, the sensitivity of HbA1c ? 6.5% was only 28.1% (110 subjects). Patients who were diabetic using 2hPG criterion but had HbA1c < 6.5% were more likely to be older (64 ± 15 versus 60 ± 15 years old, P = 0.01, mean ± STD), female (53.2% versus 38.2%, P = 0.008), leaner (29.7 ± 6.1 versus 33.0 ± 6.6 kg/m2, P = 0.00000 5), and less likely to be current smokers (18.1% versus 29.1%, P = 0.02) as compared to those with HbA1c ? 6.5%. The diagnostic agreement in the clinical setting revealed the current HbA1c ? 6.5% is less likely to detect diabetes than those defined by FPG and 2hPG. HbA1c ? 6.5% detects less than 50% of diabetic patients defined by FPG and less than 30% of diabetic patients defined by 2hPG. When the diagnosis of diabetes is in doubt by HbA1c, FPG and/or 2hPG should be obtained. ? 2016 Rudruidee Karnchanasorn et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984701374&doi=10.1155%2f2016%2f6195494&partnerID=40&md5=a1100246c53296f4e70af640007a1100 https://scholars.lib.ntu.edu.tw/handle/123456789/495703 |
ISSN: | 2314-6745 | DOI: | 10.1155/2016/6195494 | SDG/關鍵字: | glucose; hemoglobin A1c; glycosylated hemoglobin; hemoglobin A1c protein, human; adult; body mass; clinical effectiveness; cohort analysis; Conference Paper; diabetes mellitus; diabetic patient; diet restriction; early diagnosis; fasting plasma glucose; female; glucose blood level; human; lean body weight; major clinical study; male; middle aged; smoking; aged; comparative study; diet restriction; glucose blood level; glucose tolerance test; metabolism; non insulin dependent diabetes mellitus; nutrition; Adult; Aged; Blood Glucose; Cohort Studies; Diabetes Mellitus, Type 2; Fasting; Female; Glucose Tolerance Test; Glycated Hemoglobin A; Humans; Male; Middle Aged; Nutrition Surveys |
顯示於: | 醫學系 |
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