https://scholars.lib.ntu.edu.tw/handle/123456789/495724
標題: | National Surveillance for Type 2 Diabetes Mellitus in Taiwanese Children | 作者: | Wei J.-N. Sung F.-C. Lin C.-C. Lin R.-S. Chiang C.-C. LEE-MING CHUANG |
公開日期: | 2003 | 卷: | 290 | 期: | 10 | 起(迄)頁: | 1345-1350 | 來源出版物: | Journal of the American Medical Association | 摘要: | Context: Despite a disturbing trend of increasing prevalence of type 2 diabetes mellitus (DM) in childhood, little is known about the epidemiology of childhood type 2 DM, especially in the Taiwanese population. Objective: To study the rate and risk factors for childhood type 2 DM based on a nationwide screening program in Taiwan. Design, Setting, and Participants: Screening in 1999 for type 2 DM using urine and blood testing and confirmed by follow-up telephone survey among schoolchildren aged 6 to 18 years in Taiwan, followed by a nested case-control study conducted in 2002 comparing 137 children with type 2 DM with 1000 randomly selected children without diabetes chosen to represent the age and sex distribution of the whole student population. Main Outcome Measures: Rate and identification of risk factors associated with childhood type 2 DM. Results: The rate of newly identified diabetes was 9.0 per 100000 for boys and 15.3 per 100000 for girls. Follow-up at 3 years revealed that, of 253 children with newly diagnosed diabetes, 24 (9.5%) had type 1 DM, 137 (54.2%) had type 2 DM, and 22 (8.7%) had secondary diabetes. Compared with children aged 6 to 9 years, the odds ratios (ORs) and 95% confidence intervals (CIs) of type 2 DM increased to 6.59 (3.23-13.4) for those aged 13 to 15 years and to 4.59 (2.07-10.2) for those aged 16 to 18 years. The OR (95% CI) of type 2 DM in children with a body mass index in the 95th percentile or higher (obesity) was 18.8 (9.22-38.5) compared with those with a body mass index in less than the 50th percentile. Other factors significantly associated with type 2 DM were hypercholesterolemia (OR, 1.80; 95% CI, 1.04-3.23), blood pressure greater than the 85th percentile (OR, 1.70; 95% CI, 1.07-2.70), and positive family history of diabetes (OR, 3.95; 95% CI, 2.01-7.78). Conclusions: Our mass screening program showed that type 2 DM is the leading cause of childhood DM in Taiwan. Obesity is a major risk factor for the development of type 2 DM in children. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0041411078&doi=10.1001%2fjama.290.10.1345&partnerID=40&md5=1558b72f3276c199c07513b9dcc3ef56 https://scholars.lib.ntu.edu.tw/handle/123456789/495724 |
ISSN: | 0098-7484 | DOI: | 10.1001/jama.290.10.1345 | SDG/關鍵字: | adolescent; adult; age distribution; article; blood analysis; blood pressure; body mass; childhood disease; confidence interval; controlled study; family history; female; follow up; human; hypercholesterolemia; insulin dependent diabetes mellitus; male; mass screening; non insulin dependent diabetes mellitus; obesity; population; preschool child; priority journal; risk; risk factor; school child; sex ratio; student; Taiwan; telephone; urinalysis; child; health survey; statistical model; Taiwan; Adolescent; Child; Diabetes Mellitus, Type 2; Female; Humans; Logistic Models; Male; Mass Screening; Obesity; Population Surveillance; Risk Factors; Taiwan |
顯示於: | 醫學系 |
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