https://scholars.lib.ntu.edu.tw/handle/123456789/495780
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | CHO-KAI WU | en_US |
dc.contributor.author | YI-CHENG CHANG | en_US |
dc.contributor.author | Hua S.-C. | en_US |
dc.contributor.author | Wu H.-Y. | en_US |
dc.contributor.author | Lee W.-J. | en_US |
dc.contributor.author | FU-TIEN CHIANG | en_US |
dc.contributor.author | HWANG, JUEY-JEN | en_US |
dc.contributor.author | Lien W.-P. | en_US |
dc.contributor.author | LEE-MING CHUANG | en_US |
dc.creator | LEE-MING CHUANG;Lien W.-P.;Hwang J.-J.;Chiang F.-T.;Lee W.-J.;Wu H.-Y.;Hua S.-C.;Chang Y.-C.;Wu C.-K. | - |
dc.date.accessioned | 2020-06-01T04:31:38Z | - |
dc.date.available | 2020-06-01T04:31:38Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1930-7381 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77957137059&doi=10.1038%2foby.2010.10&partnerID=40&md5=3c6f6ab966edf97a4d21cbebe20ec7e3 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/495780 | - |
dc.description.abstract | Apolipoprotein A-V (apo A-V) exerts a potent triglyceride (TG)-lowering effect through enhanced intravascular TG-hydrolysis with increased uptake of TG-derived free fatty acids into muscle and adipose tissue. Genetic variants in the APOA5 gene were strongly associated with plasma TG concentrations. The aim of this study was to examine whether APOA5 genetic variation was associated with obesity. We genotyped the missense c.553 G>T polymorphism (p.G185C) in the APOA5 gene in 1,085 Chinese (333 obese subjects and 752 nonobese controls). We analyzed the association between the c.553G>T polymorphism and obesity and related metabolic phenotypes. The T allele at the c.553G>T polymorphism was associated with higher plasma TG concentrations. Each additional T allele was associated with an increased TG concentration of 53.5mg/dl (95% confidence interval (CI) 29.6-76.0, P < 0.0001). However, the T allele was associated lower risk of obesity (odds ratio (OR), 0.48; 95% CI 0.32-0.73, P = 0.0004). Each additional copy of the T allele was associated with a BMI decrease of 0.73kg/m2 (95% CI 0.26-1.16, P = 0.002), equivalent to 2.11kg in a person 1.7m tall. We may then conclude that the TG-raising APOA5 genetic variant was associated with a decrease in BMI and reduced risk of obesity in the Chinese population. ? 2010 The Obesity Society. | en_US |
dc.relation.ispartof | Obesity | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | APOA5 protein, human; apolipoprotein A; triacylglycerol; adult; aged; allele; article; Asian; blood; body mass; ethnology; female; genetic polymorphism; genetics; genotype; human; male; middle aged; obesity; risk; risk factor; Adult; Aged; Alleles; Apolipoproteins A; Asian Continental Ancestry Group; Body Mass Index; Female; Genotype; Humans; Male; Middle Aged; Obesity; Odds Ratio; Polymorphism, Genetic; Risk Factors; Triglycerides; Young Adult | - |
dc.title | A triglyceride-raising APOA5 genetic variant is negatively associated with obesity and BMI in the Chinese population | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/oby.2010.10 | - |
dc.identifier.pmid | 20134407 | - |
dc.identifier.scopus | 2-s2.0-77957137059 | - |
dc.relation.pages | 1964-1968 | en_US |
dc.relation.journalvolume | 18 | en_US |
dc.relation.journalissue | 10 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Medical Genomics and Proteomics | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-3867-150X | - |
crisitem.author.orcid | 0000-0002-8077-5011 | - |
crisitem.author.orcid | 0000-0003-4936-8968 | - |
crisitem.author.orcid | 0000-0001-6437-0455 | - |
crisitem.author.orcid | 0000-0003-0978-2662 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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