https://scholars.lib.ntu.edu.tw/handle/123456789/496129
標題: | The Influence of type 2 diabetes and glucose-lowering therapies on cancer risk in the Taiwanese | 作者: | Hsieh M.-C. Lee T.-C. Cheng S.-M. Tu S.-T. Yen M.-H. CHIN-HSIAO TSENG |
公開日期: | 2012 | 卷: | 2012 | 起(迄)頁: | 413782 | 來源出版物: | Experimental Diabetes Research | 摘要: | Objective. To investigate the association between type 2 diabetes, glucose-lowering therapies (monotherapy with either metformin, sulphonylurea or insulin) and cancer risk in Taiwan. Methods. Using Taiwans National Health Research Institutes database of 1,000,000 random subjects from 20002008, we found 61777 patients with type 2 diabetes (age 20 years) and 677378 enrollees with no record of diabetes. Results. After adjusting for age and sex, we found patients with diabetes to have significantly higher risk of all cancers (OR: 1.176; 95% CI: 1.1491.204, P 0.001). Diabetic patients treated with insulin or sulfonylureas had significantly higher risk of all cancers, compared to those treated with metformin (OR: 1.583; 95% CI: 1.3891.805, P 0.001 and OR: 1.784; 95% CI: 1.4062.262, P 0.001). Metformin treatment was associated with a decreased risk of colon and liver cancer compared to sulphonylureas or insulin treatment. Sulfonylureas treatment was associated with an increased risk of breast and lung cancer compared to metformin therapy. Conclusions. Taiwanese with type 2 diabetes are at a high risk of breast, prostate, colon, lung, liver and pancreatic cancer. Those treated with insulin or sulfonylureas monotherapy are more likely to develop colon and liver cancer than those treated with metformin. Copyright ? 2012 Ming-Chia Hsieh et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863683395&doi=10.1155%2f2012%2f413782&partnerID=40&md5=b2266adb57729d5d36de7c3063f1ce80 https://scholars.lib.ntu.edu.tw/handle/123456789/496129 |
ISSN: | 1687-5214 | DOI: | 10.1155/2012/413782 | SDG/關鍵字: | insulin; metformin; sulfonylurea; insulin; metformin; sulfonylurea derivative; adult; article; breast cancer; cancer risk; colon cancer; disease association; female; high risk patient; human; insulin treatment; liver cancer; lung cancer; major clinical study; male; monotherapy; non insulin dependent diabetes mellitus; priority journal; risk reduction; sex difference; Taiwan; aged; middle aged; neoplasm; non insulin dependent diabetes mellitus; regression analysis; risk; signal transduction; Adult; Aged; Diabetes Mellitus, Type 2; Female; Humans; Insulin; Male; Metformin; Middle Aged; Neoplasms; Odds Ratio; Regression Analysis; Risk; Sex Factors; Signal Transduction; Sulfonylurea Compounds; Taiwan |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。