https://scholars.lib.ntu.edu.tw/handle/123456789/496213
標題: | Pulse Pressure as a Risk Factor for Peripheral Vascular Disease in Type 2 Diabetic Patients | 作者: | CHIN-HSIAO TSENG | 公開日期: | 2003 | 卷: | 25 | 期: | 8 | 起(迄)頁: | 475-485 | 來源出版物: | Clinical and Experimental Hypertension | 摘要: | This study examined whether pulse pressure (PP) could be an independent predictor and associated with severity of peripheral vascular disease (PVD) in 396 type 2 diabetic patients (143 men and 253 women, aged 64.1 ± 11.2 years). Peripheral vascular disease was diagnosed by an ankle-brachial index (ABI) < 0.90 and as severe PVD if ABI < 0.80. Association was evaluated before and after adjustment for age, sex, diabetes duration, hypertension, smoking, fasting plasma glucose (FPG), total cholesterol (TC), usage of insulin, and usage of angiotensin-converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB); and for systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP), respectively. Results showed that PP increased from no (n = 348) to mild (n = 25) and severe (n = 23) PVD (one-way ANOVA, p < 0.001; multiple comparisons, p < 0.05 for any two groups), The PP increase from no to mild PVD was due to SBP increase; while further increase to severe PVD was due to both DBP drop and an even higher SBP. Adjusted odds ratio (AOR) for PVD for every 1-mmHg PP increment was 1.035 (1.012-1.058). When PP was categorized as tertiles (<50, 50-59 and > 60 mnHg), respective AOR for PVD for second and third vs. first tertile was 2.605 (1.008-6.729) and 2.835 (1.123-7.156). Pulse pressure was also predictive for ABI independent of the effects of the confounders and the other parameters of blood pressure. In conclusion, PP was an independent predictor and correlated with severity of PVD in type 2 diabetic patients. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0345327680&doi=10.1081%2fCEH-120025331&partnerID=40&md5=4480ac5c77b7a9ec8fab07cb7d6d20e0 https://scholars.lib.ntu.edu.tw/handle/123456789/496213 |
ISSN: | 1064-1963 | DOI: | 10.1081/CEH-120025331 | SDG/關鍵字: | angiotensin receptor antagonist; antihypertensive agent; dipeptidyl carboxypeptidase inhibitor; insulin; oral antidiabetic agent; adult; age; aged; analysis of variance; article; cardiovascular risk; cholesterol blood level; controlled study; correlation analysis; diagnostic procedure; diastolic blood pressure; disease association; disease duration; disease severity; evaluation; female; glucose blood level; human; hypertension; major clinical study; male; mean arterial pressure; non insulin dependent diabetes mellitus; peripheral vascular disease; prediction; pulse pressure; risk; scoring system; sex; smoking; systolic blood pressure; Aged; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Humans; Male; Middle Aged; Multivariate Analysis; Peripheral Vascular Diseases; Risk Factors; Severity of Illness Index |
顯示於: | 醫學系 |
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