https://scholars.lib.ntu.edu.tw/handle/123456789/496223
標題: | Epidemiologic evidence of diabetogenic effect of arsenic | 作者: | CHIN-HSIAO TSENG Tseng C.-P. Chiou H.-Y. Hsueh Y.-M. Chong C.-K. Chen C.-J. |
公開日期: | 2002 | 卷: | 133 | 期: | 1 | 起(迄)頁: | 69-76 | 來源出版物: | Toxicology Letters | 摘要: | It is well documented that arsenic can lead to skin lesions, atherosclerotic diseases and cancers. The association between arsenic exposure and diabetes mellitus is a relatively new finding. Up to now, there are six epidemiologic reports linking diabetes mellitus with arsenic exposure from environmental and occupational sources. Two reports in Taiwan carried out in the blackfoot disease-hyperendemic villages, one cross-sectional and one prospective follow-up of the same cohort, indicate that arsenic exposure from drinking artesian well water is associated with prevalence and incidence of diabetes mellitus in a dose-responsive pattern. The observation of the relation between arsenic exposure and diabetes mellitus is further supported by studies carried out in Sweden and Bangladesh. In Sweden, case-control analyses of death records of copper smelters and glass workers revealed a trend of increasing diabetes mellitus with increasing arsenic exposure from inhalation. In Bangladesh, prevalence of diabetes mellitus among arsenic-exposed subjects with keratosis was about five times higher than unexposed subjects. Increasing trends of diabetes mellitus with indices of arsenic exposure in drinking water seems to be independent of the presence of skin lesions associated with arsenic exposure. Although these studies consistently show an association between arsenic exposure and diabetes mellitus, the weak study designs of cross-sectional or case-control, the use of glucosuria or diabetes death as diagnostic criteria and the lack of adjustment for possible confounders in some studies, are major limitations that may reduce the strength of the evidence. ? 2002 Elsevier Science Ireland Ltd. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0037036580&doi=10.1016%2fS0378-4274%2802%2900085-1&partnerID=40&md5=e2f9331618e16792f959f3dddf9b73a1 https://scholars.lib.ntu.edu.tw/handle/123456789/496223 |
ISSN: | 0378-4274 | DOI: | 10.1016/S0378-4274(02)00085-1 | SDG/關鍵字: | arsenic; article; Bangladesh; diabetes mellitus; drinking; human; incidence; keratosis; occupational exposure; prevalence; priority journal; skin defect; smelter; Sweden; Arsenic; Bangladesh; Diabetes Mellitus; Humans; Incidence; Occupational Exposure; Retrospective Studies; Sweden; Taiwan; Water Pollution, Chemical; Melampodium |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。