https://scholars.lib.ntu.edu.tw/handle/123456789/496233
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hsueh Y.-M. | en_US |
dc.contributor.author | Wu W.-L. | en_US |
dc.contributor.author | Huang Y.-L. | en_US |
dc.contributor.author | Chiou H.-Y. | en_US |
dc.contributor.author | CHIN-HSIAO TSENG | en_US |
dc.contributor.author | Chen C.-J. | en_US |
dc.creator | Chen C.-J.;CHIN-HSIAO TSENG;Chiou H.-Y.;Huang Y.-L.;Wu W.-L.;Hsueh Y.-M. | - |
dc.date.accessioned | 2020-06-01T08:34:07Z | - |
dc.date.available | 2020-06-01T08:34:07Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0021-9150 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032403039&doi=10.1016%2fS0021-9150%2898%2900178-6&partnerID=40&md5=9324986031065ca34f7b3e576e75da1c | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/496233 | - |
dc.description.abstract | To elucidate the association between arsenic-related ischemic heart disease (ISHD) and serum antioxidant micronutrient level, residents aged 30 or older living in arseniasis-hyperendemic villages in Taiwan were recruited in a community-based health survey. A structured questionnaire was used to obtain a history of long-term exposure to arsenic through consuming artesian well water and fasting serum samples were also collected at the recruitment. A total of 74 patients affected with ISHD, who were diagnosed through both electrocardiography and Rose questionnaire interview, and 193 age-sex- matched healthy controls were selected for the examination of serum levels of micronutrients by high performance liquid chromatography (HPLC). There was a significant biological gradient between the risk of ISHD and the duration of consuming high-arsenic artesian well water. A significant reverse dose- response relationship with arsenic-related ISHD was observed for serum level of α- and β-carotene, but not for serum levels of retinol, lycopene and α- tocopherol. Multivariate analysis showed a synergistic interaction on arsenic-related ISHD between duration of consuming artesian well water and low serum carotene level. An increased risk of arsenic-related ISHD was also associated with hypertension and elevated body mass index, but not with serum lipid profile, cigarette smoking and alcohol drinking. The findings seem to suggest that arsenic-related ISHD has a pathogenic mechanism which is at least partially different from that of ISHD unrelated to long-term exposure to arsenic. | - |
dc.relation.ispartof | Atherosclerosis | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | arsenic; carotene; well water; alcohol consumption; article; blood sampling; body mass; cigarette smoking; fluid intake; high performance liquid chromatography; human; human cell; ischemic heart disease; long term exposure; malignant transformation; priority journal; risk assessment; risk factor; taiwan; Adult; Alcohol Drinking; Antioxidants; Arsenic; beta Carotene; Carotenoids; Chromatography, High Pressure Liquid; Humans; Multivariate Analysis; Myocardial Ischemia; Questionnaires; Risk Factors; Smoking; Socioeconomic Factors; Taiwan; Time Factors; Vitamin A; Vitamin E; Water Supply | - |
dc.title | Low serum carotene level and increased risk of ischemic heart disease related to long-term arsenic exposure | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/S0021-9150(98)00178-6 | - |
dc.identifier.pmid | 9862173 | - |
dc.identifier.scopus | 2-s2.0-0032403039 | - |
dc.relation.pages | 249-257 | - |
dc.relation.journalvolume | 141 | - |
dc.relation.journalissue | 2 | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0001-9545-7123 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
Appears in Collections: | 醫學系 |
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