https://scholars.lib.ntu.edu.tw/handle/123456789/496589
Title: | Serial follow-up of presurgical treatment using pasireotide long-acting release with or without octreotide long-acting release for naïve active acromegaly | Authors: | Chang J.-S. Tseng H.-M. TIEN-CHUN CHANG |
Issue Date: | 2016 | Publisher: | Elsevier B.V. | Journal Volume: | 115 | Journal Issue: | 6 | Start page/Pages: | 475-480 | Source: | Journal of the Formosan Medical Association | Abstract: | The aim of the present study was to evaluate the serial changes of GH and IGF-1 in seven patients with na?ve, active acromegaly following presurgical treatment of the somatostatin analog pasireotide long-acting release (LAR) and octreotide LAR. The patients were treated with pasireotide LAR with or without octreotide LAR for two years and underwent transsphenoidal adenomectomy. After treatment with the somatostatin analogs, the surgical cure rate was similar to that in patients who underwent transsphenoidal surgery alone. Diabetes insipidus was not identified in any patients after the operation. Pasireotide LAR was effective on GH as well as IGF-1 suppression and tumor size decreasing when used as the primary therapy. Future large-population studies to investigate the surgical curative rate after presurgical treatment with somatostatin analogs in patients with acromegaly and macroadenomas close to the cavernous sinus are warranted. However, that hyperglycemia developed following pre-surgical treatment with pasireotide should take into consideration. ? 2016. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84964679956&doi=10.1016%2fj.jfma.2016.02.003&partnerID=40&md5=f227f7a88270faae9a2ec3c879ef66b3 https://scholars.lib.ntu.edu.tw/handle/123456789/496589 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2016.02.003 | SDG/Keyword: | growth hormone; octreotide; pasireotide; somatomedin C; human growth hormone; octreotide; pasireotide; somatomedin C; somatostatin; acromegaly; adult; Article; cavernous sinus; controlled study; diabetes mellitus; double blind procedure; drug efficacy; drug withdrawal; follow up; human; hyperglycemia; hypophysis adenoma; microadenoma; multicenter study; phase 3 clinical trial; preoperative period; randomized controlled trial; transsphenoidal adenomectomy; transsphenoidal surgery; tumor volume; acromegaly; aged; analogs and derivatives; clinical trial; complication; diagnostic imaging; female; hypophysis tumor; male; metabolism; middle aged; nuclear magnetic resonance imaging; prospective study; treatment outcome; tumor volume; Acromegaly; Adult; Aged; Double-Blind Method; Female; Follow-Up Studies; Human Growth Hormone; Humans; Insulin-Like Growth Factor I; Magnetic Resonance Imaging; Male; Middle Aged; Octreotide; Pituitary Neoplasms; Prospective Studies; Somatostatin; Treatment Outcome; Tumor Burden |
Appears in Collections: | 醫學系 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.