https://scholars.lib.ntu.edu.tw/handle/123456789/496689
標題: | Three-dimensional cytomorphology in fine needle aspiration biopsy of parathyroid lesions | 作者: | TIEN-CHUN CHANG Lai S.-M. Wen C.-Y. Hsiao Y.-L. Huang S.-H. |
公開日期: | 2002 | 出版社: | S. Karger AG | 卷: | 46 | 期: | 6 | 起(迄)頁: | 1037-1042 | 來源出版物: | Acta Cytologica | 摘要: | OBJECTIVE: To elucidate three-dimensional (3-D) cytomorphology in fine needle aspiration biopsy (FNAB) of parathyroid lesions. STUDY DESIGN: Ultrasound-guided FNAB was performed on parathyroid lesions from 10 patients with hyperparathyroidism. The aspirates were stained and observed under a light microscope (LM). The aspirates were also fixed, dehydrated, critical point dried, spattered with gold ions and observed with a scanning electron microscope (SEM). Findings under SEM were correlated with the appearances under LM as well as with serum parathyroid hormone (PTH) concentrations. RESULTS: Under LM, nine cases displayed isokaryosis and one case, anisokaryosis. These appearances corresponded to isocytosis or anisocytosis under SEM. Under SEM, 3-D cytomorphology of parathyroid lesions displayed isocytotic, scattered cells in five cases, uniform cellular arrangements in four cases and anisocytotic, scattered cells in one case. The cell surface was rather smooth in five cases. The other five cases had significant granules on the cell surfaces; these all had serum PTH concentrations ? 268 pg/mL. CONCLUSION: 3-D cytomorphology in FNAB of parathyroid lesions was a rather smooth cell surface in cases with low serum PTH and a granular cell surface in cases with significantly increased serum PTH. These characteristics and the absence of microvilli might be helpful in the differential diagnosis between parathyroid and follicular thyroid lesions. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036846929&doi=10.1159%2f000327104&partnerID=40&md5=a68e1557c58c0170268c1a9bc0365cfd https://scholars.lib.ntu.edu.tw/handle/123456789/496689 |
ISSN: | 0001-5547 | DOI: | 10.1159/000327104 | SDG/關鍵字: | parathyroid hormone; adult; aged; article; aspiration biopsy; aspiration cytology; cell ultrastructure; clinical article; clinical examination; controlled study; differential diagnosis; female; human; human tissue; hyperparathyroidism; male; microvillus; parathyroid adenoma; parathyroid hormone blood level; parathyroid hyperplasia; priority journal; scanning electron microscopy |
顯示於: | 醫學系 |
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