https://scholars.lib.ntu.edu.tw/handle/123456789/496807
Title: | Asymptomatic chronic hepatitis B virus infection does not increase the risk of diabetes mellitus: A ten-year observation | Authors: | ZEI-SHUNG HUANG TIEN-SHANG HUANG TZY-HAW WU MING-FONG CHEN Hsu C.-S. JIA-HORNG KAO |
Issue Date: | 2010 | Publisher: | Blackwell Publishing | Journal Volume: | 25 | Journal Issue: | 8 | Start page/Pages: | 1420-1425 | Source: | Journal of Gastroenterology and Hepatology (Australia) | Abstract: | Background and Aim: Chronic hepatitis C virus infection has been known to increase the risk of diabetes. Whether this association holds true for chronic hepatitis B virus (HBV) infection remains unclear. We thus conducted this study to investigate the influence of asymptomatic chronic HBV infection on the incidence of diabetes in a longitudinal cohort. Methods: A total of 1233 adults who received health examinations in 1997-1998 and in 2000-2001 were enrolled. Among them, 483 subjects who received a third health examination in 2006-2008 were further sampled. The prevalence and incidence of diabetes between asymptomatic HBV carriers and non-HBV controls were compared using the χ2-test and logistic regression. Results: In 1997-1998, the prevalence rates of diabetes (9.49 and 12.0%) and glucose intolerance (28.5 and 25.4%) in HBV carriers and non-HBV controls were comparable (P > 0.05). There was no significant correlation between asymptomatic HBV infection and the presence of diabetes in subjects examined in 1997-1998, 2000-2001, or 2006-2008 when adjusted for age, gender, and body mass index (P > 0.05). In 296 non-diabetic subjects during 1997-1998, the ten-year incidence of diabetes/glucose intolerance was similar between HBV carriers and non-HBV controls (40.0 and 38.7%, P > 0.05). Moreover, no significant correlation was found between asymptomatic HBV infection and the incidence of diabetes/glucose intolerance in 2006-2008 (P = 0.775). Conclusions: Compared to non-HBV controls, subjects with asymptomatic chronic HBV infection do not have an increased risk of diabetes, and thus HBV itself is not pro-diabetic. ? 2010 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77954892255&doi=10.1111%2fj.1440-1746.2010.06268.x&partnerID=40&md5=ab3432dfb0fc518cb354279700713ab4 https://scholars.lib.ntu.edu.tw/handle/123456789/496807 |
ISSN: | 0815-9319 | DOI: | 10.1111/j.1440-1746.2010.06268.x | SDG/Keyword: | adult; article; body mass; cohort analysis; controlled study; demography; diabetes mellitus; female; glucose intolerance; hepatitis C; Hepatitis C virus; human; incidence; longitudinal study; major clinical study; male; medical examination; observational study; prevalence; priority journal; risk factor; Taiwan; virus carrier |
Appears in Collections: | 醫學系 |
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