https://scholars.lib.ntu.edu.tw/handle/123456789/496825
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | SUNG-CHING PAN | en_US |
dc.contributor.author | SZU-MIN HSIEH | en_US |
dc.contributor.author | Wang Y.-H. | en_US |
dc.contributor.author | BOR-LUEN CHIANG | en_US |
dc.contributor.author | TIEN-SHANG HUANG | en_US |
dc.contributor.author | SHAN-CHWEN CHANG | en_US |
dc.creator | Pan S.-C.;Hsieh S.-M.;Wang Y.-H.;Chiang B.-L.;Tien-Shang Huang;Chang S.-C. | - |
dc.date.accessioned | 2020-06-03T08:10:33Z | - |
dc.date.available | 2020-06-03T08:10:33Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0003-9993 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-18844410262&doi=10.1016%2fj.apmr.2004.10.017&partnerID=40&md5=ba67b7bdd5a4360ee391e4bd0dad11d4 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/496825 | - |
dc.description.abstract | Objective: To determine whether the T-cell reactivity and maturation potential of dendritic cells are impaired in subjects with spinal cord injury (SCI). Design: Cross-sectional, case-control study. Setting: University hospital in Taiwan. Participants: Thirty male SCI subjects, including 14 with paraplegia and 16 with tetraplegia, and 30 age- and sex-matched healthy controls. Interventions: Not applicable. Main Outcome Measures: CD4+ and CD8+ T-cell reactivity was assessed by lymphoproliferative response (LPR) and CD69 expression in response to stimulation with antigens, anti-CD3 monoclonal antibody, and mitogen. Dendritic cell maturation potential was assessed by phenotypic (CD80 and CD83 expression in stimulated monocyte-derived dendritic cells) and functional (the LPR of alloreactive T cells in mixed leukocyte reactions) analysis. Results: The potential of phenotypic and functional maturation of dendritic cells of subjects with SCI was significantly impaired compared with healthy controls, and that potential was worse for tetraplegic patients than for paraplegic patients. However, no significant difference was found in T-cell responses of CD4+ and CD8+ subsets between subjects with SCI and healthy controls. Conclusions: Impaired maturation potential of dendritic cells is a novel defect in innate immunity in people with SCI. ? 2005 by American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation. | - |
dc.relation.ispartof | Archives of Physical Medicine and Rehabilitation | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | antigen; B7 antigen; CD4 antigen; CD69 antigen; CD8 antigen; CD83 antigen; mitogenic agent; monoclonal antibody CD3; adult; alloimmunity; article; case control study; cell maturation; clinical article; controlled study; dendritic cell; disease severity; female; human; innate immunity; lymphoproliferative disease; male; monocyte; paraplegia; patient; phenotype; quadriplegia; spinal cord injury; T lymphocyte activation; Taiwan; university hospital; Adult; Antigens, CD; Antigens, CD4; Antigens, CD8; Antigens, CD80; Case-Control Studies; Cross-Sectional Studies; Dendritic Cells; Humans; Immunoglobulins; Male; Membrane Glycoproteins; Middle Aged; Spinal Cord Injuries; Statistics, Nonparametric; T-Lymphocytes | - |
dc.title | In vitro maturation potential of monocyte-derived dendritic cells is impaired in patients with spinal cord injury: A case-control study | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.apmr.2004.10.017 | - |
dc.identifier.pmid | 15895344 | - |
dc.identifier.scopus | 2-s2.0-18844410262 | - |
dc.relation.pages | 974-978 | - |
dc.relation.journalvolume | 86 | - |
dc.relation.journalissue | 5 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Center for Infection Control | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Oral Biology | - |
crisitem.author.dept | College of Life Science | - |
crisitem.author.dept | Immunology | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Office of the Vice President | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.orcid | 0000-0003-3154-6690 | - |
crisitem.author.orcid | 0000-0002-1879-4086 | - |
crisitem.author.orcid | 0000-0002-6705-0286 | - |
crisitem.author.orcid | 0000-0003-0505-8511 | - |
crisitem.author.orcid | 0000-0001-6505-4139 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | Administrative Unit | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
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