https://scholars.lib.ntu.edu.tw/handle/123456789/502677
Title: | Zebrafish as a model for the study of human myeloid malignancies | Authors: | Lu J.-W. Hsieh M.-S. Liao H.-A. Yang Y.-J. Ho Y.-J. LIANG-IN LIN |
Issue Date: | 2015 | Journal Volume: | 2015 | Start page/Pages: | 641475 | Source: | BioMed Research International | Abstract: | Myeloid malignancies are heterogeneous disorders characterized by uncontrolled proliferation or/and blockage of differentiation of myeloid progenitor cells. Although a substantial number of gene alterations have been identified, the mechanism by which these abnormalities interact has yet to be elucidated. Over the past decades, zebrafish have become an important model organism, especially in biomedical research. Several zebrafish models have been developed to recapitulate the characteristics of specific myeloid malignancies that provide novel insight into the pathogenesis of these diseases and allow the evaluation of novel small molecule drugs. This report will focus on illustrative examples of applications of zebrafish models, including transgenesis, zebrafish xenograft models, and cell transplantation approaches, to the study of human myeloid malignancies. ? 2015 Jeng-Wei Lu et al. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/502677 | ISSN: | 2314-6133 | DOI: | 10.1155/2015/641475 | SDG/Keyword: | imatinib; retinoic acid; acute myeloblastic leukemia; Article; disease model; drug screening; hematopoiesis; hematopoietic stem cell transplantation; leukemogenesis; myelodysplastic syndrome; myeloproliferative neoplasm; nonhuman; transgenics; tumor xenograft; zebra fish; animal; genetics; human; Leukemia, Myeloid; pathology; transgenic animal; zebra fish; Danio rerio; Animals; Animals, Genetically Modified; Disease Models, Animal; Humans; Leukemia, Myeloid; Xenograft Model Antitumor Assays; Zebrafish |
Appears in Collections: | 醫學檢驗暨生物技術學系 |
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