https://scholars.lib.ntu.edu.tw/handle/123456789/502685
Title: | MicroRNA let-7a-3 gene methylation is associated with karyotyping, CEBPA promoter methylation, and survival in acute myeloid leukemia | Authors: | Ko Y.-C. WOEI-HORNG FANG Lin T.-C. HSIN-AN HOU Chen, Chien-Yuan HWEI-FANG TIEN LIANG-IN LIN |
Issue Date: | 2014 | Journal Volume: | 38 | Journal Issue: | 5 | Start page/Pages: | 625-631 | Source: | Leukemia Research | Abstract: | Let-7a-3 transcribes the miRNA let-7a, of which the expression is dysregulated in cancer. We evaluated the significance of let-7a-3 gene methylation in patients with de novo acute myeloid leukemia (AML). Let-7a-3 was methylated in 81.1% (73/90), partially methylated in 12.2% (11/90), or unmethylated in 6.7% (6/90) of patients. Let-7a-3 methylation correlated with AML karyotyping and CCAAT/enhancer binding protein α (CEBPA) methylation. Kaplan-Meier survival analysis predicted that let-7a-3 hypermethylation correlated with better survival in AML with hypomethylated CEBPA or with hypomethylated CEBPA without the favorable karyotype. We conclude that let-7a-3 methylation is a positive prognosticator for AML patients with hypomethylated CEBPA. ? 2014 Elsevier Ltd. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/502685 | ISSN: | 0145-2126 | DOI: | 10.1016/j.leukres.2014.03.008 | SDG/Keyword: | Acute myeloid leukemia; CCAAT/enhancer binding protein α; DNA methylation; miRNA let-7a-3; Adolescent; Adult; Aged; Aged, 80 and over; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; DNA Methylation; Humans; Karyotyping; Leukemia, Myeloid, Acute; MicroRNAs; Middle Aged; Promoter Regions, Genetic |
Appears in Collections: | 醫學檢驗暨生物技術學系 |
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