https://scholars.lib.ntu.edu.tw/handle/123456789/502694
Title: | Resveratrol enhances the expression of death receptor Fas/CD95 and induces differentiation and apoptosis in anaplastic large-cell lymphoma cells | Authors: | Ko Y.-C. Chang C.-L. Chien H.-F. Wu C.-H. LIANG-IN LIN |
Issue Date: | 2011 | Journal Volume: | 309 | Journal Issue: | 1 | Start page/Pages: | 46-53 | Source: | Cancer Letters | Abstract: | Resveratrol (3,5,4′-trihydroxy-trans-stilbene), a phytoalexin found in grapes and other plants, plays a protective role in human atherosclerosis and carcinogenesis. We examined the effects of resveratrol on the anaplastic large-cell lymphoma (ALCL) cell line SR-786. Resveratrol inhibited growth and induced cellular differentiation, as demonstrated by morphological changes and elevated expression of T cell differentiation markers CD2, CD3, and CD8. Resveratrol also triggered cellular apoptosis, as demonstrated by morphological observations, DNA fragmentation, and cell cycle analyses. Further, the surface expression of the death receptor Fas/CD95 was increased by resveratrol treatment. Our data suggest that resveratrol may have potential therapeutic value for ALCL. ? 2011 Elsevier Ireland Ltd. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/502694 | ISSN: | 0304-3835 | DOI: | 10.1016/j.canlet.2011.05.014 | SDG/Keyword: | CD2 antigen; CD3 antigen; CD8 antigen; Fas antigen; resveratrol; apoptosis; article; cancer inhibition; cell cycle; cell differentiation; cell structure; concentration response; controlled study; DNA fragmentation; drug effect; IC 50; large cell lymphoma; lymphoma cell; lymphoma cell line; priority journal; protein expression; Anticarcinogenic Agents; Antigens, CD95; Apoptosis; Cell Cycle; Cell Differentiation; Cell Line, Tumor; DNA Fragmentation; Humans; Lymphoma, Large-Cell, Anaplastic; Stilbenes; Vitaceae |
Appears in Collections: | 醫學檢驗暨生物技術學系 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.