https://scholars.lib.ntu.edu.tw/handle/123456789/502706
Title: | Expression of angiopoietins and vascular endothelial growth factors and their clinical significance in acute myeloid leukemia | Authors: | HSIN-AN HOU WEN-CHIEN CHOU LIANG-IN LIN JIH-LUH TANG Tseng M.-H. Huang C.-F. MING YAO Chen, Chien-Yuan WOEI TSAY HWEI-FANG TIEN |
Issue Date: | 2008 | Journal Volume: | 32 | Journal Issue: | 6 | Start page/Pages: | 904-912 | Source: | Leukemia Research | Abstract: | Angiogenic factors play an essential role in normal and pathologic angiogenesis, but their clinical role in acute myeloid leukemia (AML) remains unclear. We investigated the expression of Ang-1, Ang-2, Tie2, VEGF-A, and VEGF-C genes in bone marrow (BM) mononuclear cells by real-time quantitative PCR (RQ-PCR) in a cohort of 126 patients with newly diagnosed de novo AML and normal marrow donors. Here we show that high pre-treatment levels of Ang-2 in the BM indicate an unfavorable prognosis in AML. Only karyotype (hazard ratio 2.19, 95% CI 1.25-3.42, P = 0.005) and expression of Ang-2 (hazard ratio 2.05, 95% CI 1.20-3.52, P = 0.009), but not other angiogenic factors, were independent prognostic factors for overall survival by multivariate analysis. The prognostic significance of Ang-2 expression was more obvious in the subgroup of patients with intermediate-risk cytogenetics. Subgroup analysis showed that Ang-2 expression had prognostic impact on patients with low (but not high) Ang-1 or Tie2 levels, and on patients with high (but not low) VEGF-A or VEGF-C levels. ? 2007 Elsevier Ltd. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/502706 | ISSN: | 0145-2126 | DOI: | 10.1016/j.leukres.2007.08.010 | SDG/Keyword: | angiopoietin 1; angiopoietin 2; angiopoietin receptor; cytarabine; daunorubicin; idarubicin; vasculotropin A; vasculotropin C; acute granulocytic leukemia; adolescent; adult; aged; article; cancer chemotherapy; clinical feature; combination chemotherapy; controlled study; cytogenetics; drug megadose; female; human; human cell; karyotype; major clinical study; male; monotherapy; outcome assessment; overall survival; priority journal; prognosis; protein expression; reverse transcription polymerase chain reaction; Adolescent; Adult; Aged; Aged, 80 and over; Angiopoietin-1; Angiopoietin-2; Bone Marrow; Cohort Studies; DNA Primers; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation, Leukemic; Humans; Immunoenzyme Techniques; Leukemia, Myeloid, Acute; Male; Middle Aged; Prognosis; Receptor, TIE-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Rate; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor C |
Appears in Collections: | 醫學檢驗暨生物技術學系 |
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