https://scholars.lib.ntu.edu.tw/handle/123456789/502708
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | DA-LIANG OU | en_US |
dc.contributor.author | Chien H.-F. | en_US |
dc.contributor.author | Chen C.-L. | en_US |
dc.contributor.author | Lin T.-C. | en_US |
dc.contributor.author | LIANG-IN LIN | en_US |
dc.creator | Ou D.-L.;Chien H.-F.;Chen C.-L.;Lin T.-C.;Liang-In Lin | - |
dc.date.accessioned | 2020-06-16T07:53:40Z | - |
dc.date.available | 2020-06-16T07:53:40Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/502708 | - |
dc.description.abstract | The transcription factor Twist protein has been found to be correlated with metastasis in various carcinomas, including hepatocellular, breast and prostate carcinomas. However, the role of Twist in head and neck squamous cell carcinomas (HNSCC) remains unknown. Head and neck cancer tissue microarrays (TMAs) of tumors from 50 patients with HNSCC were examined. Immunohistochemical (IHC) stain analysis showed that, out of the 50 patients, twenty (40%) showed Twist-positive staining in the tumor cells, and Twist expression was positively associated with differentiation status (p=0.027), lymph node metastasis (p=0.032) and disease progression (p=0.029). Further analysis revealed that the expression of Twist was positively correlated with CXCR4 (Spearman, r=0.408, p=0.003) and CCR7 (r=0.417, p=0.003). FindPatterns analysis suggested that the transcription factor Twist, as a basic helix-loop-helix (bHLH) protein, might regulate CXCR4 and CCR7 expression in squamous cell carcinomas, which in turn might be associated with lymph node metastasis. | en_US |
dc.relation.ispartof | Anticancer Research | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | chemokine receptor CCR7; chemokine receptor CXCR4; helix loop helix protein; transcription factor Twist; adult; aged; article; clinical article; disease course; female; head and neck carcinoma; human; human tissue; immunohistochemistry; lymph node metastasis; male; priority journal; protein expression; squamous cell carcinoma; tissue microarray; Cell Nucleus; Cytoplasm; Female; Head and Neck Neoplasms; Humans; Immunohistochemistry; Lymphatic Metastasis; Male; Middle Aged; Nuclear Proteins; Protein Array Analysis; Receptors, CCR7; Receptors, Chemokine; Receptors, CXCR4; Receptors, Virus; Twist Transcription Factor | - |
dc.title | Role of twist in head and neck carcinoma with lymph node metastasis | en_US |
dc.type | journal article | en |
dc.identifier.pmid | 18505078 | - |
dc.identifier.scopus | 2-s2.0-42549134455 | - |
dc.relation.pages | 1355-1359 | en_US |
dc.relation.journalvolume | 28 | en_US |
dc.relation.journalissue | 2 B | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Oncology | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.orcid | 0000-0002-8368-1141 | - |
crisitem.author.orcid | 0000-0002-3561-1093 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學檢驗暨生物技術學系 |
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