https://scholars.lib.ntu.edu.tw/handle/123456789/502715
標題: | Nucleophosmin mutations in de novo acute myeloid leukemia: The age-dependent incidences and the stability during disease evolution | 作者: | WEN-CHIEN CHOU JIH-LUH TANG LIANG-IN LIN MING YAO WOEI TSAY Chen, Chien-Yuan SHANG-JU WU Huang C.-F. Chiou R.-J. Tseng M.-H. Lin D.-T. Lin K.-H. YAO-CHANG CHEN HWEI-FANG TIEN |
公開日期: | 2006 | 卷: | 66 | 期: | 6 | 起(迄)頁: | 3310-3316 | 來源出版物: | Cancer Research | 摘要: | Nucleophosmin (NPM) mutations have been found in a significant proportion of adults with de novo acute myeloid leukemia (AML), especially in those of a normal karyotype. These results provide a basis for studies of the pathogenesis in this specific subgroup of AML. In this study, NPM mutations were analyzed in 173 Chinese patients of de novo AML, including adults and children. We found that NPM mutations were present in 19.1% of the overall population and 40.3% of those with a normal karyotype. Adults had a significantly higher incidence of NPM mutations than children [32 of 126 (25.4%) versus 1 of 47 (2.1%), P < 0.001]. NPM mutations were closely associated with normal karyotype (P < 0.001) and internal tandem duplication of FLT3 (P = 0.002), but negatively associated with CEBPA mutations (P = 0.032) and expression of CD34 (P < 0.001) and HLA-DR (P = 0.003). Serial analyses of NPM mutations showed the mutation disappeared at complete remission, but the same mutation reappeared at relapse, except for one who lost the mutation at the second relapse, when new cytogenetic abnormalities emerged. None acquired novel mutations during the follow-up period. In conclusion, NPM mutations occur in an age-dependent fashion. Moreover, the findings that NPM mutations are stable during disease evolution and closely associated with disease status make it a potential marker for monitoring minimal residual disease. ?2006 American Association for Cancer Research. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/502715 | ISSN: | 0008-5472 | DOI: | 10.1158/0008-5472.CAN-05-4316 | SDG/關鍵字: | CD34 antigen; HLA DR antigen; nucleophosmin; acute granulocytic leukemia; adult; age; antigen expression; article; cancer relapse; cebpa gene; child; Chinese; chromosome aberration; diagnostic value; female; flt3 gene; follow up; gene; gene duplication; gene mutation; human; incidence; karyotype; leukemogenesis; major clinical study; male; minimal residual disease; npm gene; priority journal; remission; Taiwan; Acute Disease; Adolescent; Adult; Age Factors; Aged; Amino Acid Sequence; Base Sequence; Child; Child, Preschool; Disease Progression; Exons; Female; Humans; Immunophenotyping; Infant; Leukemia, Myeloid; Male; Middle Aged; Molecular Sequence Data; Mutation; Nuclear Proteins |
顯示於: | 醫學檢驗暨生物技術學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。