https://scholars.lib.ntu.edu.tw/handle/123456789/502914
標題: | Expression and prognostic significance of the apoptotic genes BCL2L13, Livin, and CASP8AP2 in childhood acute lymphoblastic leukemia | 作者: | YUNG-LI YANG Lin S.-R. Chen J.-S. SHU-WHA LIN SUNG-LIANG YU Chen H.-Y. Yen C.-T. Lin C.-Y. Lin J.-F. Lin K.-H. SHIANN-TANG JOU CHUNG-YI HU Chang S.-K. MENG-YAO LU HSIU-HAO CHANG Chang W.-H. Lin K.-S. Lin D.-T. |
公開日期: | 2010 | 卷: | 34 | 期: | 1 | 起(迄)頁: | 18-23 | 來源出版物: | Leukemia Research | 摘要: | Improved treatment of childhood acute lymphoblastic leukemia (ALL) depends on the identification of new molecular markers that are able to predict treatment response and clinical outcome. The development of impaired apoptosis in leukemic cells is one factor that may influence their response to treatment. We investigated the expression of three apoptosis related genes, BCL2L13, CASP8AP2, and Livin, as well as their prognostic significance, in a retrospective study of 90 pediatric ALL patients diagnosed between 1996 and 2007 in Taiwan. Univariant analysis revealed that high expression of BCL2L13 was associated with inferior event-free survival and overall survival (p < 0.001 and 0.005, respectively). Multivariate analysis for EFS and OS demonstrated that high expression of BCL2L13 was an independent prognostic factor for childhood ALL in this ethnic group. ? 2009 Elsevier Ltd. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/502914 | ISSN: | 0145-2126 | DOI: | 10.1016/j.leukres.2009.07.023 | SDG/關鍵字: | caspase 8 associated protein 2; gene product; livin; protein BCL2L13; unclassified drug; acute lymphoblastic leukemia; adolescent; apoptosis; article; cancer survival; child; childhood leukemia; controlled study; event free survival; female; gene expression; genetic association; genetic marker; human; infant; leukemia cell; major clinical study; male; overall survival; preschool child; priority journal; prognosis; school child; Adaptor Proteins, Signal Transducing; Adolescent; Apoptosis; Apoptosis Regulatory Proteins; Calcium-Binding Proteins; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Inhibitor of Apoptosis Proteins; Male; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Proportional Hazards Models; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction |
顯示於: | 醫學檢驗暨生物技術學系 |
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